BROMINATED POLYACETYLENIC ACIDS FROM THE MARINE SPONGE XESTOSPONGIA-MUTA - INHIBITORS OF HIV PROTEASE

被引：76

作者：

PATIL, AD ^{[1
]}

KOKKE, WC ^{[1
]}

COCHRAN, S ^{[1
]}

FRANCIS, TA ^{[1
]}

TOMSZEK, T ^{[1
]}

WESTLEY, JW ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT MED CHEM,KING OF PRUSSIA,PA 19406

来源：

JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 09期

关键词：

D O I：

10.1021/np50087a002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The EtOAc extract of the sponge Xestospongia muta collected in Colombus Island, Bahamas, yielded eleven straight-chain unsaturated, polyacetylenic, brominated acids, seven of which were identified on the basis of spectral data, including the unknown acids 2-7. These acetylenic acids are the first known examples that have been shown to inhibit HIV protease, a critical enzyme in the replication of human immunodeficiency virus.

引用

页码：1170 / 1177

页数：8

共 14 条

[1]

[Anonymous], 1973, NATURALLY OCCURRING

[2] HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE - A TARGET FOR AIDS THERAPY [J].

DEBOUCK, C ;

METCALF, BW .

DRUG DEVELOPMENT RESEARCH, 1990, 21 (01) :1-17

[3]

HIRSH S, 1987, TETRAHEDRON, P3257

[4] PURIFICATION AND SOME KINETIC-PROPERTIES OF RAT-LIVER ATP-CITRATE LYASE [J].

HOUSTON, B ;

NIMMO, HG .

BIOCHEMICAL JOURNAL, 1984, 224 (02) :437-443

[5]

LAMBERT DM, 1990, ANN NY ACAD SCI, V616, P552

[6] HIV WITH REDUCED SENSITIVITY TO ZIDOVUDINE (AZT) ISOLATED DURING PROLONGED THERAPY [J].

LARDER, BA ;

DARBY, G ;

RICHMAN, DD .

SCIENCE, 1989, 243 (4899) :1731-1734

[7]

Meek TD, 1990, DESIGN ANTIAIDS DRUG, P225

[8]

Mollering H., 1985, METHOD ENZYMAT AN, P39

[9] NOVEL ACETYLENIC ACIDS FROM THE ROOT BARK OF PARAMACROLOBIUM-CAERULEUM - INHIBITORS OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE [J].

PATIL, AD ;

CHAN, JA ;

LOISFLAMBERG, P ;

MAYER, RJ ;

WESTLEY, JW .

JOURNAL OF NATURAL PRODUCTS, 1989, 52 (01) :153-161

[10] FURTHER ACETYLENIC ACIDS FROM THE MARINE SPONGE XESTOSPONGIA-TESTUDINARIA [J].

QUINN, RJ ;

TUCKER, DJ .

JOURNAL OF NATURAL PRODUCTS, 1991, 54 (01) :290-294

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