NOVEL ACETYLENIC ACIDS FROM THE ROOT BARK OF PARAMACROLOBIUM-CAERULEUM - INHIBITORS OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE

被引：17

作者：

PATIL, AD

CHAN, JA

LOISFLAMBERG, P

MAYER, RJ

WESTLEY, JW

机构：

[1] SK&F LABS,DEPT BIOMOLEC DISCOVERY,RES & DEV,POB 1539,KING OF PRUSSIA,PA 19406

[2] SK&F LABS,DEPT MED CHEM,RES & DEV,KING OF PRUSSIA,PA 19406

来源：

JOURNAL OF NATURAL PRODUCTS | 1989年 / 52卷 / 01期

关键词：

D O I：

10.1021/np50061a020

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

引用

页码：153 / 161

页数：9

共 19 条

[1] MEVINOLIN - A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME-A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT [J].

ALBERTS, AW ;

CHEN, J ;

KURON, G ;

HUNT, V ;

HUFF, J ;

HOFFMAN, C ;

ROTHROCK, J ;

LOPEZ, M ;

JOSHUA, H ;

HARRIS, E ;

PATCHETT, A ;

MONAGHAN, R ;

CURRIE, S ;

STAPLEY, E ;

ALBERSSCHONBERG, G ;

HENSENS, O ;

HIRSHFIELD, J ;

HOOGSTEEN, K ;

LIESCH, J ;

SPRINGER, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (07) :3957-3961

[2]

[Anonymous], 1973, NATURALLY OCCURRING

[3] INVESTIGATION OF COMPLEX NETWORKS OF SPIN-SPIN COUPLING BY TWO-DIMENSIONAL NMR [J].

BAX, A ;

FREEMAN, R .

JOURNAL OF MAGNETIC RESONANCE, 1981, 44 (03) :542-561

[4]

EDWARDS PA, 1979, J LIPID RES, V20, P40

[5] MONACOLIN-K, A NEW HYPOCHOLESTEROLEMIC AGENT THAT SPECIFICALLY INHIBITS 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE [J].

ENDO, A .

JOURNAL OF ANTIBIOTICS, 1980, 33 (03) :334-336

[6] BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY OF INHIBITORS OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE [J].

ENDO, A .

TRENDS IN BIOCHEMICAL SCIENCES, 1981, 6 (01) :10-13

[7] ML-236A, ML-236B, AND ML-236C, NEW INHIBITORS OF CHOLESTEROGENESIS PRODUCED BY PENICILLIUM CITRINUM [J].

ENDO, A ;

KURODA, M ;

TSUJITA, Y .

JOURNAL OF ANTIBIOTICS, 1976, 29 (12) :1346-1348

[8]

GRUNDY SM, 1978, WESTERN J MED, V128, P13

[9] FATTY ACIDS .23. NUCLEAR MAGNETIC RESONANCE SPECTRA OF SOME OCTADECADIYNOIC ACIDS AND OF SOME METHYL CIS, CIS-OCTADECADIENOATES AND TRANS, TRANS-OCTADECADIENOATES [J].

GUNSTONE, FD ;

JIE, MLK ;

WALL, RT .

CHEMISTRY AND PHYSICS OF LIPIDS, 1969, 3 (04) :297-&

[10]

GUNSTONE FD, 1967, CHEM PHYS LIPIDS, V1, P264

← 1 2 →