MOLECULAR-CLONING OF A NEW MEMBER OF THE RAB PROTEIN FAMILY, RAB-26, FROM RAT PANCREAS

被引：19

作者：

WAGNER, ACC

STROWSKI, MZ

GOKE, B

WILLIAMS, JA

机构：

[1] UNIV MARBURG,DEPT GASTROENTEROL,D-35033 MARBURG,GERMANY

[2] UNIV MICHIGAN,DEPT PHYSIOL,ANN ARBOR,MI 48109

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 207卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.1277

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Members of the Rab family of low molecular weight GTP-binding (LMWG) proteins regulate vesicular transport; distinct Rab proteins are located in specific vesicular compartments within the exocytotic and endocytotic pathway. Pancreatic zymogen granules possess multiple LMWG. Rab 3A however, which has been suggested to regulate exocytosis of synaptic vesicles, is not present in rat pancreatic acinar cells or on zymogen granules (BBRC 1994,269:542-548). To look for homologues of Rab 3A we have screened a rat pancreatic cDNA library using Rab 3A as a probe. We now report the cDNA and deduced amino acid sequence of a new member of the Rab protein family. Rab 26 is a 190 AA protein with a predicted molecular mass of 21,459 Dalton. It is expressed in pancreas, kidney, brain, submandibular gland, and lung. It is most closely related to Rab 8. There is also close homology to Rab 15, Sec4 and Rab 3. (C) 1995 Academic Press, Inc.

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页码：950 / 956

页数：7

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