STUDIES ON SUSPENSION AND EMULSION .138. COMPETITIVE ADSORPTION OF FIBRINOGEN AND ALBUMIN ONTO POLYMER MICROSPHERES HAVING HYDROPHILIC/HYDROPHOBIC HETEROGENEOUS SURFACE-STRUCTURES
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作者:
OKUBO, M
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机构:Department of Industrial Chemistry, Faculty of Engineering, Kobe University, Nada, Kobe, 657, Rokko
OKUBO, M
HATTORI, H
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机构:Department of Industrial Chemistry, Faculty of Engineering, Kobe University, Nada, Kobe, 657, Rokko
HATTORI, H
机构:
[1] Department of Industrial Chemistry, Faculty of Engineering, Kobe University, Nada, Kobe, 657, Rokko
The competitive adsorption of bovine fibrinogen (BFb) and bovine serum albumin onto polymer microspheres from the mixture solution was examined under various protein-to-microsphere ratios using various homopolymer microspheres and poly(2-hydroxyethyl methacrylate)/polystyrene composite microspheres having heterogeneous surface structures consisting of both hydrophilic and hydrophobic parts. They were produced by emulsifier-free (seeded) emulsion polymerizations. The selective adsorption of BFb was not observed for the homopolymer microspheres, but observed for the composite polymer microspheres having optimum compositions.