NICOTINE AND BRAIN-STIMULATION REWARD - INTERACTIONS WITH MORPHINE, AMPHETAMINE AND PIMOZIDE

被引：33

作者：

HUSTONLYONS, D ^{[1
]}

SARKAR, M ^{[1
]}

KORNETSKY, C ^{[1
]}

机构：

[1] BOSTON UNIV,SCH MED,BEHAV PHARMACOL LAB,BOSTON,MA 02118

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1993年 / 46卷 / 02期

关键词：

SELF-STIMULATION; OPIATE; PSYCHOMOTOR STIMULANT; DOPAMINE RECEPTOR ANTAGONIST;

D O I：

10.1016/0091-3057(93)90378-7

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Using a rate-independent discrete trial method of determining thresholds for rewarding electrical intracranial stimulation in rats, we evaluated the pharmacological interaction of nicotine plus morphine, d-amphetamine, or the D-2 receptor antagonist, pimozide. Both morphine and amphetamine shifted the dose-response curve for nicotine down and to the left, indicating increased efficacy and potency, respectively. Pimozide at doses that have no effect on performance and only minimal effect on brain-stimulation reward blocked the effect of nicotine. These data suggest that the same dopaminergic substrate that supports the positive reinforcing effects of other drugs of abuse also supports nicotine reward.

引用

页码：453 / 457

页数：5

共 28 条

[21] NEGATIVE AND POSITIVE INTRACRANIAL REINFORCEMENT THRESHOLDS - EFFECTS OF MORPHINE [J].

MARCUS, R ;

KORNETSKY, C .

PSYCHOPHARMACOLOGIA, 1974, 38 (01) :1-13

[22] EFFECTS OF CHOLINERGIC AGONISTS AND ANTAGONISTS ON SELF-STIMULATION BEHAVIOR IN RAT [J].

NEWMAN, LM .

JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1972, 79 (03) :394-&

[23]

OLDS ME, 1969, J PHARMACOL EXP THER, V166, P189

[24]

PRADHAN SN, 1971, J PHARMACOL EXP THER, V176, P229

[25] TASK-SPECIFIC EFFECTS OF NICOTINE IN RATS - INTRACRANIAL SELF-STIMULATION AND LOCOMOTOR-ACTIVITY [J].

SCHAEFER, GJ ;

MICHAEL, RP .

NEUROPHARMACOLOGY, 1986, 25 (02) :125-131

[26] ACTION OF DRUGS OF ABUSE ON BRAIN REWARD SYSTEMS [J].

WISE, RA .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1980, 13 :213-223

[27]

WISE RA, 1992, NEUROBIOLOGY DRUG AL, P192

[28]

WOOD PL, 1988, PHARMACOL REV, V40, P163

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