CHARACTERISTICS OF RENAL TRANSPORT OF TAURINE IN REPTILIAN BRUSH-BORDER MEMBRANES

被引:14
作者
BENYAJATI, S
JOHNSON, JL
机构
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1991年 / 260卷 / 05期
关键词
TAURINE SECRETION AND REABSORPTION; LUMINAL MEMBRANES; VESICLES; BETA-AMINO ACIDS; SODIUM CHLORIDE GRADIENT; KIDNEY; SNAKE; THAMNOPHIS-SIRTALIS;
D O I
10.1152/ajpregu.1991.260.5.R879
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We examined characteristics of taurine transport across renal brush-border membranes (BBM) of the garter snake (Thamnophis sirtalis), a species that demonstrates both net reabsorption and secretion of taurine in vivo. Transport was examined by a rapid filtration technique at 25-degrees-C. Inwardly directed Na+ gradient specifically stimulated taurine uptake. Under initial taurine equilibrium condition, a small overshoot of taurine uptake driven by an inwardly directed NaCl gradient could be observed. No stimulation of taurine uptake was observed under Na+ equilibrium or K+, Li+, or choline gradients conditions. Reptilian renal BBM taurine transport also displayed specific Cl- requirement: replacement of NaCl by NaSCN or Na+-gluconate gradients inhibited taurine uptake. The uptake was stimulated under Cl- gradient compared with Cl- equilibrium conditions. Taurine transport was not stimulated by H+ gradient in either direction, although it was inhibited by acidic pH (< 7.0). Amiloride and furosemide had no effects. The transport was electrogenic, stimulated by an inside negative membrane potential, and inhibited by other beta-amino acids. Overall, the reptilian BBM transport system for taurine resembles those observed in both mammalian and fish renal BBM.
引用
收藏
页码:R879 / R888
页数:10
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