REACTIVITY OF PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE-PEROXIDASE WITH MEMBRANE AND LIPOPROTEIN LIPID HYDROPEROXIDES

被引：73

作者：

MAIORINO, M ^{[1
]}

THOMAS, JP ^{[1
]}

GIROTTI, AW ^{[1
]}

URSINI, F ^{[1
]}

机构：

[1] MED COLL WISCONSIN,DEPT BIOCHEM,MILWAUKEE,WI 53226

来源：

FREE RADICAL RESEARCH COMMUNICATIONS | 1991年 / 12-3卷

关键词：

LIPID HYDROPEROXIDES; GLUTATHIONE; SE-PEROXIDASES;

D O I：

10.3109/10715769109145777

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A comparative study has been carried out on the general reactivity of lipid hydroperoxides in liposornes, biological membranes and lipoproteins with two Se-dependent peroxidases: Glutathione Peroxidase (GPX) and Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPX). While PHGPX reduces all hydroperoxides derived from phospholipids, cholesterol and cholesterol esters, GPX reduces only fatty acid hydroperoxides released after treatment of phospholipid hydroperoxides with phospholipase A,. These findings highlight the role of PHGPX in protecting biomembranes from peroxidative damage and add new insight into how cholesterol hydroperoxides are detossified in cells. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

收藏

页码：131 / 135

页数：5

相关论文

共 9 条

[1] ASCORBATE-ENHANCED LIPID-PEROXIDATION IN PHOTOOXIDIZED CELL-MEMBRANES - CHOLESTEROL PRODUCT ANALYSIS AS A PROBE OF REACTION-MECHANISM [J].

BACHOWSKI, GJ ;

THOMAS, JP ;

GIROTTI, AW .

LIPIDS, 1988, 23 (06) :580-586

[2] NON-REACTIVITY OF THE SELENOENZYME GLUTATHIONE-PEROXIDASE WITH ENZYMATICALLY HYDROPEROXIDIZED PHOSPHOLIPIDS [J].

GROSSMANN, A ;

WENDEL, A .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1983, 135 (03) :549-552

[3]

MAIORINO M, 1982, BIOCHEM INT, V5, P575

[4] DIFFERENT EFFECTS OF TRITON-X-100, DEOXYCHOLATE, AND FATTY-ACIDS ON THE KINETICS OF GLUTATHIONE-PEROXIDASE AND PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE-PEROXIDASE [J].

MAIORINO, M ;

ROVERI, A ;

GREGOLIN, C ;

URSINI, F .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1986, 251 (02) :600-605

[5] MICROSOMAL LIPID-PEROXIDATION - EFFECT OF VITAMIN-E AND ITS FUNCTIONAL INTERACTION WITH PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE-PEROXIDASE [J].

MAIORINO, M ;

COASSIN, M ;

ROVERI, A ;

URSINI, F .

LIPIDS, 1989, 24 (08) :721-726

[6] THE INFLUENCE OF PHOSPHOLIPASE-A2 AND GLUTATHIONE-PEROXIDASE ON THE ELIMINATION OF MEMBRANE LIPID PEROXIDES [J].

SEVANIAN, A ;

MUAKKASSAHKELLY, SF ;

MONTESTRUQUE, S .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1983, 223 (02) :441-452

[7] PHOTOOXIDATION OF CELL-MEMBRANES IN THE PRESENCE OF HEMATOPORPHYRIN DERIVATIVE - REACTIVITY OF PHOSPHOLIPID AND CHOLESTEROL HYDROPEROXIDES WITH GLUTATHIONE-PEROXIDASE [J].

THOMAS, JP ;

GIROTTI, AW .

BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 962 (03) :297-307

[8] PURIFICATION FROM PIG-LIVER OF A PROTEIN WHICH PROTECTS LIPOSOMES AND BIOMEMBRANES FROM PEROXIDATIVE DEGRADATION AND EXHIBITS GLUTATHIONE-PEROXIDASE ACTIVITY ON PHOSPHATIDYLCHOLINE HYDROPEROXIDES [J].

URSINI, F ;

MAIORINO, M ;

VALENTE, M ;

FERRI, L ;

GREGOLIN, C .

BIOCHIMICA ET BIOPHYSICA ACTA, 1982, 710 (02) :197-211

[9] THE SELENOENZYME PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE-PEROXIDASE [J].

URSINI, F ;

MAIORINO, M ;

GREGOLIN, C .

BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 839 (01) :62-70