BIOTRANSFORMATION OF ORGANIC SULFIDES .6. FORMATION OF CHIRAL PARASUBSTITUTED BENZYL METHYL SULFOXIDES BY HELMINTHOSPORIUM SPECIES NRRL-4671

被引：26

作者：

HOLLAND, HL

BROWN, FM

LARSEN, BG

机构：

[1] Department of Chemistry, Brock University, St. Catharines

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 07期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/0957-4166(95)00199-Y

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The fungus Helminthosporium species NRRL 4671 has been used for the biotransformation of a series of para-substituted benzyl sulfides with substituent groups consisting of trifluoromethyl, halo, hydroxy, methoxy, acetoxy, nitro, cyano, amino, acetamido, acyl and carboxylic acid units. In all cases, sulfoxide formation occurred in good yield and with predominant (S) chirality at the sulfur position. A minor amount of sulfone product was also obtained from the halo- and methoxy-substituted substrates.

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页码：1561 / 1567

页数：7

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