EVALUATION OF THE POTENT ANTI-HEPATITIS-B VIRUS AGENT (-)CIS-5-FLUORO-1-[2-(HYDROXYMETHYL)-1,3-OXATHIOLAN-5-YL]CYTOSINE IN A NOVEL IN-VIVO MODEL

被引：35

作者：

CONDREAY, LD

JANSEN, RW

POWDRILL, TF

JOHNSON, LC

SELLESETH, DW

PAFF, MT

DALUGE, SM

PAINTER, GR

FURMAN, PA

ELLIS, MN

AVERETT, DR

机构：

[1] WELLCOME RES LABS,DIV VIROL,RES TRIANGLE PK,NC 27709

[2] WELLCOME RES LABS,DIV ORGAN CHEM,RES TRIANGLE PK,NC 27709

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 03期

关键词：

D O I：

10.1128/AAC.38.3.616

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A murine model was developed to investigate the in vivo activity of anti-hepatitis B virus (HBV) agents. Mice with subcutaneous tumors of HBV-producing 2.2.15 cells showed reductions in levels of HBV in serum and in intracellular levels of HBV when the mice were orally dosed with (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,-3-oxathiolan-5-yl] cytosine (FTC). No effects on tumor size or alpha-fetoprotein levels were observed. FTC can selectively inhibit HBV replication at nontoxic doses.

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收藏

页码：616 / 619

页数：4

相关论文

共 26 条

[1] EFFICIENT DUCK HEPATITIS-B VIRUS PRODUCTION BY AN AVIAN LIVER-TUMOR CELL-LINE [J].

CONDREAY, LD ;

ALDRICH, CE ;

COATES, L ;

MASON, WS ;

WU, TT .

JOURNAL OF VIROLOGY, 1990, 64 (07) :3249-3258

[2] INDUCTION OF DRUG-METABOLIZING ENZYMES IN HUMAN-LIVER CELL-LINE HEP-G2 [J].

DAWSON, JR ;

ADAMS, DJ ;

WOLF, CR .

FEBS LETTERS, 1985, 183 (02) :219-222

[3] INHIBITION OF THE REPLICATION OF HEPATITIS-B VIRUS INVITRO BY 2',3'-DIDEOXY-3'-THIACYTIDINE AND RELATED ANALOGS [J].

DOONG, SL ;

TSAI, CH ;

SCHINAZI, RF ;

LIOTTA, DC ;

CHENG, YC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (19) :8495-8499

[4] THE INFLUENCE OF CULTURE-MEDIUM COMPOSITION ON DRUG-METABOLIZING ENZYME-ACTIVITIES OF THE HUMAN-LIVER DERIVED HEP-G2 CELL-LINE [J].

DOOSTDAR, H ;

DUTHIE, SJ ;

BURKE, MD ;

MELVIN, WT ;

GRANT, MH .

FEBS LETTERS, 1988, 241 (1-2) :15-18

[5]

Frick, COMMUNICATION

[6] THE ANTI-HEPATITIS-B VIRUS ACTIVITIES, CYTOTOXICITIES, AND ANABOLIC PROFILES OF THE (-) AND (+) ENANTIOMERS OF CIS-5-FLUORO-1-[2-(HYDROXYMETHYL)-1,3-OXATHIOLAN-5-YL]CYTOSINE [J].

FURMAN, PA ;

DAVIS, M ;

LIOTTA, DC ;

PAFF, M ;

FRICK, LW ;

NELSON, DJ ;

DORNSIFE, RE ;

WURSTER, JA ;

WILSON, LJ ;

FYFE, JA ;

TUTTLE, JV ;

MILLER, WH ;

CONDREAY, L ;

AVERETT, DR ;

SCHINAZI, RF ;

PAINTER, GR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (12) :2686-2692

[7]

GERBER MA, 1988, LAB INVEST, V59, P173

[8] EFFECTS OF ADENINE-ARABINOSIDE ON SERUM AND INTRAHEPATIC REPLICATIVE FORMS OF DUCK HEPATITIS-B VIRUS IN CHRONIC INFECTION [J].

HIROTA, K ;

SHERKER, AH ;

OMATA, M ;

YOKOSUKA, O ;

OKUDA, K .

HEPATOLOGY, 1987, 7 (01) :24-28

[9]

HUBER BE, 1985, CANCER RES, V45, P4322

[10]

JANSEN RW, 1993, ANTIMICROB AGENTS CH, V37, P471