EVALUATION OF THE POTENT ANTI-HEPATITIS-B VIRUS AGENT (-)CIS-5-FLUORO-1-[2-(HYDROXYMETHYL)-1,3-OXATHIOLAN-5-YL]CYTOSINE IN A NOVEL IN-VIVO MODEL

被引：35

作者：

CONDREAY, LD

JANSEN, RW

POWDRILL, TF

JOHNSON, LC

SELLESETH, DW

PAFF, MT

DALUGE, SM

PAINTER, GR

FURMAN, PA

ELLIS, MN

AVERETT, DR

机构：

[1] WELLCOME RES LABS,DIV VIROL,RES TRIANGLE PK,NC 27709

[2] WELLCOME RES LABS,DIV ORGAN CHEM,RES TRIANGLE PK,NC 27709

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 03期

关键词：

D O I：

10.1128/AAC.38.3.616

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A murine model was developed to investigate the in vivo activity of anti-hepatitis B virus (HBV) agents. Mice with subcutaneous tumors of HBV-producing 2.2.15 cells showed reductions in levels of HBV in serum and in intracellular levels of HBV when the mice were orally dosed with (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,-3-oxathiolan-5-yl] cytosine (FTC). No effects on tumor size or alpha-fetoprotein levels were observed. FTC can selectively inhibit HBV replication at nontoxic doses.

引用

收藏

页码：616 / 619

页数：4

相关论文

共 26 条

[11] HUMAN HEPATOCELLULAR-CARCINOMA CELL-LINES SECRETE THE MAJOR PLASMA-PROTEINS AND HEPATITIS-B SURFACE-ANTIGEN [J].

KNOWLES, BB ;

HOWE, CC ;

ADEN, DP .

SCIENCE, 1980, 209 (4455) :497-499

[12] A CELL-CULTURE ASSAY FOR COMPOUNDS WHICH INHIBIT HEPATITIS-B VIRUS-REPLICATION [J].

KORBA, BE ;

MILMAN, G .

ANTIVIRAL RESEARCH, 1991, 15 (03) :217-228

[13] INVITRO AND INVIVO COMPARISON OF THE ABILITIES OF PURINE AND PYRIMIDINE 2',3'-DIDEOXYNUCLEOSIDES TO INHIBIT DUCK HEPADNAVIRUS [J].

LEE, B ;

LUO, WX ;

SUZUKI, S ;

ROBINS, MJ ;

TYRRELL, DLJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (03) :336-339

[14]

Lofgren B, 1990, ANTIVIR CHEM CHEMOTH, V1, P361

[15] THE PROBLEM OF ANTIVIRAL THERAPY FOR CHRONIC HEPADNAVIRUS INFECTIONS [J].

MASON, WS .

JOURNAL OF HEPATOLOGY, 1993, 17 :S137-S142

[16] INHIBITION OF INTRAHEPATIC HEPATITIS-B VIRUS-REPLICATION BY ANTIVIRAL DRUGS IN A NOVEL TRANSGENIC MOUSE MODEL [J].

NAGAHATA, T ;

ARAKI, K ;

YAMAMURA, KI ;

MATSUBARA, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (09) :2042-2045

[17]

NORDENFELT E, 1982, ACTA PATH MICRO IM B, V90, P449

[18] THE MECHANISM OF INHIBITION OF HEPATITIS-B VIRUS-REPLICATION BY THE CARBOCYCLIC ANALOG OF 2'-DEOXYGUANOSINE [J].

PRICE, PM ;

BANERJEE, R ;

JEFFREY, AM ;

ACS, G .

HEPATOLOGY, 1992, 16 (01) :8-12

[19] INHIBITION OF THE REPLICATION OF HEPATITIS-B VIRUS BY THE CARBOCYCLIC ANALOG OF 2'-DEOXYGUANOSINE [J].

PRICE, PM ;

BANERJEE, R ;

ACS, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (21) :8541-8544

[20] PRODUCTION OF HEPATITIS-B VIRUS-PARTICLES IN HEP-G2 CELLS TRANSFECTED WITH CLONED HEPATITIS-B VIRUS-DNA [J].

SELLS, MA ;

CHEN, ML ;

ACS, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (04) :1005-1009