UTEROPLACENTAL CARBON SUBSTRATE METABOLISM AND O-2 CONSUMPTION AFTER LONG-TERM HYPOGLYCEMIA IN PREGNANT SHEEP

被引:40
作者
CARVER, TD [1 ]
HAY, WW [1 ]
机构
[1] UNIV COLORADO, SCH MED, DEPT PEDIAT, DIV PERINATAL MED & RES, DENVER, CO 80262 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 1995年 / 269卷 / 02期
关键词
PLACENTA; FETUS; GLUCOSE; FRUCTOSE; ACETOACETATE; BETA-HYDROXYBUTYRATE; AMINO ACIDS; INSULIN; INTRAUTERINE GROWTH RESTRICTION;
D O I
10.1152/ajpendo.1995.269.2.E299
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Chronic maternal hypoglycemia leads to fetal growth restriction, but the effects an placental metabolism and its contribution to reduced fetal growth have not been determined. To study these factors, experiments were conducted in seven normal control (C) and six chronically insulin-infused hypoglycemic (H) pregnant sheep over the second half of gestation to measure effects of maternal and fetal hypoglycemia [maternal: 2.0 +/- 0.2 (H) vs. 3.6 +/- 0.1 mM (C); fetal: 0.7 +/- 0.1 (H) vs. 1.1 +/- 0.1 mM (C)] on placental metabolism of glucose, other carbon substrates, and O-2. Placental and fetal weight were proportionately reduced in the H group [placental wt: 258 +/- 18 (H) vs. 376 +/- 18 g (C), -31%; fetal wt: 2,540 +/- 190 (H) vs. 3,558 +/- 230 g (C), -29%]. Glucose uptake by the uterus was reduced in the H group [0.10 +/- 0.01 (H) vs. 0.19 +/- 0.02 mmol/min (C)]; it was partitioned more to uteroplacental consumption (UPGC) and less to transfer to the fetus (PGT) [UPGC-to-PGT ratio: 20.0 +/- 2.1 (H) and 13.5 +/- 1.2 (C), P < 0.05 for both]. Metabolism of glucose by nonoxidative and oxidative pathways (as estimated by uteroplacental lactate production-to-UPGC ratio and normal rates of placental O-2 consumption) was not significantly changed in the H group. Acetoacetate and beta-hydroxybutyrate net uptake and fructose production rates were significantly reduced in the H group, and there was no change in free fatty acid or amino acid uptake rates. With acute return of maternal and fetal glucose concentrations to normal, UPGC and PGT exceeded normal rates by similar to 25%. Thus chronic reduced glucose supply to the uteroplacenta produces a smaller placenta that uses glucose normally and in preference to transfer to the fetus, demonstrating placental metabolic autonomy at the expense of the fetus.
引用
收藏
页码:E299 / E308
页数:10
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