GENETIC-DETERMINANTS OF DIASTOLIC AND PULSE PRESSURE MAP TO DIFFERENT LOCI IN LYON HYPERTENSIVE RATS

被引：126

作者：

DUBAY, C

VINCENT, M

SAMANI, NJ

HILBERT, P

KAISER, MA

BERESSI, JP

KOTELEVTSEV, Y

BECKMANN, JS

SOUBRIER, F

SASSARD, J

LATHROP, GM

机构：

[1] CTR ETUD POLYMORPHISME HUMAIN,INSERM,U358,F-75010 PARIS,FRANCE

[2] FAC PHARM LYON,DEPT PHYSIOL & PHARMACOL CLIN,CNRS,URA 1483,F-69373 LYON,FRANCE

[3] UNIV LEICESTER,ROYAL INFIRM,DEPT MED,LEICESTER LE2 7LX,ENGLAND

[4] IRIBNH,B-1070 BRUSSELS,BELGIUM

[5] COLL FRANCE,INSERM,U36,F-75005 PARIS,FRANCE

来源：

NATURE GENETICS | 1993年 / 3卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/ng0493-354

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Several genetic loci involved in blood pressure regulation have recently been localized in experimental models of hypertension, but the manner in which they influence blood pressure remains unknown. Here, we report a study of the Lyon hypertensive rat strain showing that different loci are involved in the regulation of steady-state (diastolic pressure) and pulsatile (systolic - diastolic, or pulse pressure) components of blood pressure. Significant linkage was established between diastolic blood pressure and a microsatellite marker of the renin gene (REN) on rat chromosome 13, and between pulse pressure and the carboxypeptidase B gene (CPB) on chromosome 2. These findings show that two independent loci influence different haemodynamic components of blood pressure, and that pulse pressure has a specific genetic determination.

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页码：354 / 357

页数：4

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