INVOLVEMENT OF NITRIC-OXIDE IN LONG-TERM POTENTIATION IN THE DENTATE GYRUS INVIVO

被引：56

作者：

MIZUTANI, A ^{[1
]}

SAITO, H ^{[1
]}

ABE, K ^{[1
]}

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL,TOKYO 113,JAPAN

来源：

BRAIN RESEARCH | 1993年 / 605卷 / 02期

关键词：

NITRIC OXIDE; LONG-TERM POTENTIATION; DENTATE GYRUS; ANESTHETIZED RAT;

D O I：

10.1016/0006-8993(93)91756-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Effects of NO synthase inhibitors on long-term potentiation (LTP) were investigated in the dentate gyrus of anesthetized rats. Administration of N(G)-nitro-L-arginine methyl ester (L-NAME; 50 nmol i.c.v.) greatly blocked the generation of LTP without affecting basal responses. N(G)-nitro-L-arginine (50 nmol) or N(G)-methyl-L-arginine (50 nmol) also showed similar effects. The LTP-blocking effect of L-NAME was reversed by coadministration of L-arginine (500 nmol). These results suggest that NO participates in the generation of LTP at the dentate gyrus in vivo.

引用

页码：309 / 311

页数：3

共 17 条

[1] POSSIBLE INVOLVEMENT OF NITRIC-OXIDE IN LONG-TERM POTENTIATION [J].

BOHME, GA ;

BON, C ;

STUTZMANN, JM ;

DOBLE, A ;

BLANCHARD, JC .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 199 (03) :379-381

[2] LOCALIZATION OF NITRIC-OXIDE SYNTHASE INDICATING A NEURAL ROLE FOR NITRIC-OXIDE [J].

BREDT, DS ;

HWANG, PM ;

SNYDER, SH .

NATURE, 1990, 347 (6295) :768-770

[3] NITRIC-OXIDE SYNTHASE PROTEIN AND MESSENGER-RNA ARE DISCRETELY LOCALIZED IN NEURONAL POPULATIONS OF THE MAMMALIAN CNS TOGETHER WITH NADPH DIAPHORASE [J].

BREDT, DS ;

GLATT, CE ;

HWANG, PM ;

FOTUHI, M ;

DAWSON, TM ;

SNYDER, SH .

NEURON, 1991, 7 (04) :615-624

[4] ISOLATION OF NITRIC-OXIDE SYNTHETASE, A CALMODULIN-REQUIRING ENZYME [J].

BREDT, DS ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) :682-685

[5] EXCITATORY AMINO-ACIDS IN SYNAPTIC TRANSMISSION IN THE SCHAFFER COLLATERAL COMMISSURAL PATHWAY OF THE RAT HIPPOCAMPUS [J].

COLLINGRIDGE, GL ;

KEHL, SJ ;

MCLENNAN, H .

JOURNAL OF PHYSIOLOGY-LONDON, 1983, 334 (JAN) :33-46

[6] NITRIC-OXIDE MEDIATES GLUTAMATE NEUROTOXICITY IN PRIMARY CORTICAL CULTURES [J].

DAWSON, VL ;

DAWSON, TM ;

LONDON, ED ;

BREDT, DS ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (14) :6368-6371

[7] LONG-TERM POTENTIATION IN THE DENTATE GYRUS - INDUCTION AND INCREASED GLUTAMATE RELEASE ARE BLOCKED BY D(-)AMINOPHOSPHONOVALERATE [J].

ERRINGTON, ML ;

LYNCH, MA ;

BLISS, TVP .

NEUROSCIENCE, 1987, 20 (01) :279-284

[8] ENDOTHELIUM-DERIVED RELAXING FACTOR RELEASE ON ACTIVATION OF NMDA RECEPTORS SUGGESTS ROLE AS INTERCELLULAR MESSENGER IN THE BRAIN [J].

GARTHWAITE, J ;

CHARLES, SL ;

CHESSWILLIAMS, R .

NATURE, 1988, 336 (6197) :385-388

[9] NMDA RECEPTOR ACTIVATION INDUCES NITRIC-OXIDE SYNTHESIS FROM ARGININE IN RAT-BRAIN SLICES [J].

GARTHWAITE, J ;

GARTHWAITE, G ;

PALMER, RMJ ;

MONCADA, S .

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1989, 172 (4-5) :413-416

[10] THE ROLE OF NITRIC-OXIDE IN HIPPOCAMPAL LONG-TERM POTENTIATION [J].

HALEY, JE ;

WILCOX, GL ;

CHAPMAN, PF .

NEURON, 1992, 8 (02) :211-216

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