INVOLVEMENT OF NITRIC-OXIDE IN LONG-TERM POTENTIATION IN THE DENTATE GYRUS INVIVO

被引：56

作者：

MIZUTANI, A ^{[1
]}

SAITO, H ^{[1
]}

ABE, K ^{[1
]}

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL,TOKYO 113,JAPAN

来源：

BRAIN RESEARCH | 1993年 / 605卷 / 02期

关键词：

NITRIC OXIDE; LONG-TERM POTENTIATION; DENTATE GYRUS; ANESTHETIZED RAT;

D O I：

10.1016/0006-8993(93)91756-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Effects of NO synthase inhibitors on long-term potentiation (LTP) were investigated in the dentate gyrus of anesthetized rats. Administration of N(G)-nitro-L-arginine methyl ester (L-NAME; 50 nmol i.c.v.) greatly blocked the generation of LTP without affecting basal responses. N(G)-nitro-L-arginine (50 nmol) or N(G)-methyl-L-arginine (50 nmol) also showed similar effects. The LTP-blocking effect of L-NAME was reversed by coadministration of L-arginine (500 nmol). These results suggest that NO participates in the generation of LTP at the dentate gyrus in vivo.

引用

页码：309 / 311

页数：3

共 17 条

[11] LONG-TERM POTENTIATION IN THE HIPPOCAMPUS INVOLVES ACTIVATION OF N-METHYL-D-ASPARTATE RECEPTORS [J].

HARRIS, EW ;

GANONG, AH ;

COTMAN, CW .

BRAIN RESEARCH, 1984, 323 (01) :132-137

[12] FORMATION OF NITRIC-OXIDE FROM L-ARGININE IN THE CENTRAL NERVOUS-SYSTEM - A TRANSDUCTION MECHANISM FOR STIMULATION OF THE SOLUBLE GUANYLATE-CYCLASE [J].

KNOWLES, RG ;

PALACIOS, M ;

PALMER, RMJ ;

MONCADA, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (13) :5159-5162

[13] TESTS OF THE ROLES OF 2 DIFFUSIBLE SUBSTANCES IN LONG-TERM POTENTIATION - EVIDENCE FOR NITRIC-OXIDE AS A POSSIBLE EARLY RETROGRADE MESSENGER [J].

ODELL, TJ ;

HAWKINS, RD ;

KANDEL, ER ;

ARANCIO, O .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (24) :11285-11289

[14] NITRIC-OXIDE RELEASE ACCOUNTS FOR THE BIOLOGICAL-ACTIVITY OF ENDOTHELIUM-DERIVED RELAXING FACTOR [J].

PALMER, RMJ ;

FERRIGE, AG ;

MONCADA, S .

NATURE, 1987, 327 (6122) :524-526

[15] A REQUIREMENT FOR THE INTERCELLULAR MESSENGER NITRIC-OXIDE IN LONG-TERM POTENTIATION [J].

SCHUMAN, EM ;

MADISON, DV .

SCIENCE, 1991, 254 (5037) :1503-1506

[16] NITRIC-OXIDE AS A NEURONAL MESSENGER [J].

SNYDER, SH ;

BREDT, DS .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (04) :125-128

[17] LONG-TERM POTENTIATION [J].

TEYLER, TJ ;

DISCENNA, P .

ANNUAL REVIEW OF NEUROSCIENCE, 1987, 10 :131-161

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