MITOCHONDRIAL DISEASES - GENOTYPE VERSUS PHENOTYPE

被引:100
作者
WALLACE, DC
机构
[1] Department of Genetics and Molecular Medicine, Emory University Medical School, Atlanta, GA 30322
关键词
D O I
10.1016/0168-9525(93)90207-X
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Recently, a variety of degenerative diseases have been attributed to mutations in mitochondrial DNA. Even though these mutations are inherited and present throughout the body, they frequently cause late-onset, tissue-specific disease. This may be explained by a combination of the tissue-specific accumulation of somatic mtDNA mutations with age and the variation between tissues in the expression of nuclear genes that encode mitochondrial functions.
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收藏
页码:128 / 133
页数:6
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