EFFECTS OF THE 5-HT1A RECEPTOR AGONIST 8-OH-DPAT AND OTHER NON-PHOTIC STIMULI ON THE CIRCADIAN-RHYTHM OF WHEEL-RUNNING ACTIVITY IN HAMSTERS UNDER DIFFERENT CONSTANT CONDITIONS

被引：54

作者：

CUTRERA, RA ^{[1
]}

OUAROUR, A ^{[1
]}

PEVET, P ^{[1
]}

机构：

[1] UNIV STRASBOURG 1,CNRS,URA 1332,F-67000 STRASBOURG,FRANCE

来源：

NEUROSCIENCE LETTERS | 1994年 / 172卷 / 1-2期

关键词：

GOLDEN HAMSTER; SEROTONIN; 8-OH-DPAT; 5-HT1A RECEPTOR; SUPRACHIASMATIC NUCLEUS; RAPHE NUCLEUS; WHEEL-RUNNING; NON-PHOTIC STIMULUS;

D O I：

10.1016/0304-3940(94)90654-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Our findings show that administration of the 5-HT1A receptor agonist 8-OH-DPAT (8-hydroxy-2-[di-n-propylamino] tetralin) was able to induce significant phase-advances 4 h before onset of hamster locomotor activity under constant darkness. All other non-photic treatments applied such as melatonin, dimethyl sulphoxide, Ringer, saline or enforced wheel-running failed to induce any significant phase-advances. Similar results were obtained in pinealectomized animals. In constant light (LL), all treatments produced phase-advances. These results show that: (1) LL seems to be an inappropriate constant condition to study the chronobiological effect of drugs or other non-photic stimuli; (2) the endogenous circadian pacemaker (SCN) can be affected specifically by 8-OH-DPAT.

引用

页码：27 / 30

页数：4

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