DETECTION OF EPSTEIN-BARR-VIRUS DNA IN CEREBROSPINAL-FLUID FOR DIAGNOSIS OF AIDS-RELATED CENTRAL-NERVOUS-SYSTEM LYMPHOMA

被引:75
作者
ARRIBAS, JR
CLIFFORD, DB
FICHTENBAUM, CJ
ROBERTS, RL
POWDERLY, WG
STORCH, GA
机构
[1] WASHINGTON UNIV,SCH MED,DEPT MED,ST LOUIS,MO 63138
[2] WASHINGTON UNIV,SCH MED,DEPT NEUROL,ST LOUIS,MO 63138
[3] WASHINGTON UNIV,SCH MED,DEPT PATHOL,ST LOUIS,MO 63138
[4] WASHINGTON UNIV,SCH MED,DEPT PEDIAT,ST LOUIS,MO 63138
关键词
D O I
10.1128/JCM.33.6.1580-1583.1995
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The diagnostic utility of Epstein-Barr virus (EBV) DNA detection in cerebrospinal fluid for the diagnosis of central nervous system lymphoma was evaluated with two different PCR assays to test a collection of cerebrospinal fluid samples from 24 AIDS patients with central nervous system disorders, A PCR assay amplifying a fragment from the BamHI-W region had the highest clinical and analytic sensitivity. The BamHI-W PCR assay detected EBV DNA in cerebrospinal fluid from 83% (5 of 6) of patients with pathologically proven primary central nervous system lymphoma and 7% (1 of 16) of controls with autopsy-proven nonlymphomatous central nervous system disorders. EBV DNA was also detected in one patient with autopsy-proven systemic lymphoma involving the central nervous system and one patient with probable primary central nervous system lymphoma. EBV DNA was detected consistently when central nervous system lymphoma involved meningeal surfaces. PCR for EBV in cerebrospinal fluid appears to be useful for diagnosis of AIDS-related central nervous system lymphoma, but additional studies are required to better define the sensitivity of the assay and to understand the significance of a positive test in the absence of lymphoma.
引用
收藏
页码:1580 / 1583
页数:4
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