HIGHLY SUBSTITUTED CIS-BETA-CYCLOPENTANE AMINO-ACIDS - AN APPROACH TO THE SYNTHESIS OF TREHAZOLIN ANALOGS

被引：16

作者：

ELLIOTT, RP

HUI, A

FAIRBANKS, AJ

NASH, RJ

WINCHESTER, BG

WAY, G

SMITH, C

LAMONT, RB

STORER, R

FLEET, GWJ

机构：

[1] OXFORD CTR MOLEC SCI,DYSON PERRINS LAB,OXFORD OX1 3QY,ENGLAND

[2] AFRC,INST GRASSLAND & ENVIRONM RES,ABERYSTWYTH SY23 3EB,DYFED,WALES

[3] UNIV LONDON,INST CHILD HLTH,LONDON WC1N 1EH,ENGLAND

[4] GLAXO GRP RES LTD,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 49期

关键词：

D O I：

10.1016/S0040-4039(00)61520-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient aldol condensation of a 2-iodo-5-formyl-1,5-lactone provides a short route to precursors for both cis-beta-cyclopentane amino acids and trehalostatin analogues with control of the stereochemistry at all 5 carbons of the cyclopentane ring.

引用

页码：7949 / 7952

页数：4

共 21 条

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