MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I MOLECULES ARE REQUIRED FOR THE DEVELOPMENT OF INSULITIS IN NONOBESE DIABETIC MICE

被引:180
作者
KATZ, J
BENOIST, C
MATHIS, D
机构
[1] CNRS,GENET MOLEC EUCARYOTES LAB,11 RUE HUMANN,F-67085 STRASBOURG,FRANCE
[2] INST CHIM BIOL,INSERM,UNITE BIOL MOLEC 184,STRASBOURG,FRANCE
关键词
MAJOR HISTOCOMPATIBILITY COMPLEX; DIABETES; AUTOIMMUNE DISEASE; NONOBESE DIABETIC MICE; KNOCK-OUT MICE;
D O I
10.1002/eji.1830231244
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
An early step in the development of autoimmune diabetes is lymphocyte infiltration into the islets of Langerhans of the pancreas, or insulitis. The infiltrate contains both CD4+ and CD8+ T cells and both are required for progression to diabetes in non-obese diabetic (NOD) mice. It has been thought that the CD4+ lymphocytes are the initiators of the disease, the islet invaders, while CD8+ cells are the effectors, the islet destroyers. We question this interpretation because NOD mice lacking MHC class I molecules, hence CD8+ T cells, do not display even insulitis when expected.
引用
收藏
页码:3358 / 3360
页数:3
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