DEVELOPMENT OF A MICROSATELLITE GENETIC-MAP SPANNING 5Q31-Q33 AND SUBSEQUENT PLACEMENT OF THE LGMD1A LOCUS BETWEEN D5S178 AND IL9

被引：25

作者：

YAMAOKA, LH

WESTBROOK, CA

SPEER, MC

GILCHRIST, JM

JABS, EW

SCHWEINS, EG

STAJICH, JM

GASKELL, PC

ROSES, AD

PERICAKVANCE, MA

机构：

[1] UNIV CHICAGO,DEPT MED,CHICAGO,IL 60637

[2] RHODE ISL HOSP,PROVIDENCE,RI 02902

[3] BROWN UNIV,PROVIDENCE,RI 02912

[4] JOHNS HOPKINS UNIV,SCH MED,BALTIMORE,MD

[5] DUKE UNIV,MED CTR,DEPT NEUROBIOL,DURHAM,NC 27710

来源：

NEUROMUSCULAR DISORDERS | 1994年 / 4卷 / 5-6期

关键词：

D O I：

10.1016/0960-8966(94)90086-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000:1.

引用

页码：471 / 475

页数：5

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