THE FUNCTION OF METALLOTHIONEIN

被引：264

作者：

VALLEE, BL

机构：

[1] Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Boston, MA 02115

来源：

NEUROCHEMISTRY INTERNATIONAL | 1995年 / 27卷 / 01期

关键词：

D O I：

10.1016/0197-0186(94)00165-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since its discovery in 1957 metallothionein (MT) has remained a protein in search of a function. After 40 years of frustrating efforts, three areas of research point to its zinc cluster structure as the basis of its functional potential: (1) the regulation of MT gene expression by zinc-dependent transcription factors, (2) neuronal growth inhibition in brain, and (3) interactions with glutathione and zinc proteins.

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页码：23 / 33

页数：11

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