ALPHA(2)-ADRENERGIC RECEPTOR SENSITIVITY IN PANIC DISORDER .1. GH RESPONSE TO GHRH AND CLONIDINE STIMULATION IN PANIC DISORDER

被引：28

作者：

BRAMBILLA, F ^{[1
]}

PERNA, G ^{[1
]}

GARBERI, A ^{[1
]}

NOBILE, P ^{[1
]}

BELLODI, L ^{[1
]}

机构：

[1] UNIV MILAN,IST SCI SAN RAFFAELE,DIPARTIMENTO SCI NEUROPSICHICHE,MILAN,ITALY

来源：

PSYCHONEUROENDOCRINOLOGY | 1995年 / 20卷 / 01期

关键词：

GROWTH HORMONE; SOMATOMEDIN C; GHRH TEST; CLONIDINE TEST; ALPRAZOLAM; ALPHA(2)ADRENOCEPTORS;

D O I：

10.1016/0306-4530(94)E0021-Z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Baseline levels of GH and somatomedin C (SmC) and GH responses to GHRH (1 mu g/kg b.w.) and to clonidine (150 mu g) were measured in 10 outpatients with panic disorder before and after 30 days of 2-2.5 mg of alprazolam therapy, and in 10 psychophysically healthy controls. Basal levels of GH were normal in the patients and those of SmC significantly elevated, both before and after therapy. Basal GH responses to GHRH stimulation were normal and did not change after alprazolam treatment. Basal GH responses to clonidine stimulation were blunted in the patients and improved after therapy, in parallel with an amelioration of the psychopathology. Our data suggest that adrenoceptor sensitivity, investigated by the clonidine test, is reduced in panic disorder.

引用

页码：1 / 9

页数：9

共 26 条

[1] ENDOCRINE, CARDIOVASCULAR, AND BEHAVIORAL-RESPONSES TO CLONIDINE IN PATIENTS WITH PANIC DISORDER [J].