INHIBITION OF STEROID NUCLEUS DEGRADATION IN MYCOBACTERIAL TRANSFORMATIONS

被引：54

作者：

WIX, G

BUKI, KG

TOMORKENY, E

AMBRUS, G

机构：

[1] Research Institute for Pharmaceutical Chemistry, Budapest

来源：

STEROIDS | 1968年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0039-128X(68)80150-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Screening a large number of Mycobacteria showed that most of them metabolize cholesterol (cholest-5-en-3β-ol) and cholest-4-en-3-one resp., and some of them accumulate androsta-1,4-diene-3,17-dione when the steroid nucleus break-down is inhibited. The 9α-hydroxylation which initiates the degradation of steroids was inhibited by chelating agents. The Mycobacterium phlei strain, studied extensively, formed Δ1,4-3-keto and rostadienes from 5α- and 5β-saturated, Δ1-, Δ4- and Δ5-double bond containing androstanes and 17β-side chain containing steroids reap. © 1968.

引用

页码：401 / +

页数：1