NOVEL CARBOCYCLIC NUCLEOSIDES RELATED TO OXETANOCIN

被引：17

作者：

JOHNSON, CR

DEJONG, RL

机构：

[1] Department of Chemistry, Wayne State University, Detroit

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 02期

关键词：

D O I：

10.1021/jo00028a036

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Carbocyclic oxetanocin analogues 9-[trans-2,cis-3-bis(hydroxymethyl)-5,9-dithiaspiro-[3.5]non-r-1-yl]adenine, 9-[4,4-dimethyl-trans-2,cis-3-bis(hydroxymethyl)cyclobut-r-1-yl]adenine, and related compounds have been prepared by a strategy utilizing nucleophilic addition of heterocyclic bases to dimethyl 4,4-disubstituted 2-cyclobutene-1,2-dicarboxylates. The latter were prepared by a process involving [2 + 2] cycloadditions of enamines and dimethyl maleate.

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页码：594 / 599

页数：6

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