Extracellular Vesicles in Hematological Disorders

被引：22

作者：

Aharon, Anat ^{[1
,2
]}

Rebibo-Sabbah, Annie ^{[1
,2
]}

Tzoran, Inna ^{[1
,2
,3
]}

Levin, Carina ^{[1
,2
,4
,5
]}

机构：

[1] Rambam Hlth Care Campus

[2] Technion Israel Inst Technol, Bruce Rappaport Fac Med, Haifa, Israel

[3] Rambam Hlth Care Campus, Dept Internal Med C, Haifa, Israel

[4] Emek Med Ctr, Pediat Hematol Unit, Afula, Israel

[5] Emek Med Ctr, Pediat Dept B, Afula, Israel

来源：

RAMBAM MAIMONIDES MEDICAL JOURNAL | 2014年 / 5卷 / 04期

关键词：

Extracellular vesicles; exosomes; microRNA; thrombogenicity; hemoglobinopathies; leukemia; myeloma; lymphomas;

D O I：

10.5041/RMMJ.10166

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Extracellular vesicles (EVs), comprised of exosomes, microparticles, apoptotic bodies, and other microvesicles, are shed from a variety of cells upon cell activation or apoptosis. EVs promote clot formation, mediate pro-inflammatory processes, transfer proteins and miRNA to cells, and induce cell signaling that regulates cell differentiation, proliferation, migration, invasion, and apoptosis. This paper will review the contribution of EVs in hematological disorders, including hemoglobinopathies (sickle cell disease, thalassemia), paroxysmal nocturnal hemoglobinuria, and hematological malignancies (lymphomas, myelomas, and acute and chronic leukemias).

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