COPPER-METABOLISM IN THE LEC RAT - INVOLVEMENT OF INDUCTION OF METALLOTHIONEIN AND DISPOSITION OF ZINC AND IRON

被引：66

作者：

SUGAWARA, N ^{[1
]}

SUGAWARA, C ^{[1
]}

KATAKURA, M ^{[1
]}

TAKAHASHI, H ^{[1
]}

MORI, M ^{[1
]}

机构：

[1] SAPPORO MED COLL,DEPT PATHOL,SAPPORO,HOKKAIDO 060,JAPAN

来源：

EXPERIENTIA | 1991年 / 47卷 / 10期

关键词：

LEC RAT; COPPER; METALLOTHIONEIN; CERULOPLASMIN; ZINC; IRON;

D O I：

10.1007/BF01923342

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Cu concentration was about 40 times higher in the liver of LEC (Long-Evans with a cinnamon-like coat color) rats aged 77 days (227.5 +/- 21.6-mu-g/g liver) than in Fischer rats (5.2 +/- 0.1-mu-g/g liver). However, in the kidney and brain of the LEC rats, Cu concentrations were lower than in these organs of the Fischer rats. Cu concentration in the hepatic metallothionein fraction was about 130 times higher in the LEC rats than in the Fischer rats. The LEC rats showed markedly low concentrations of Cu in the serum and bile. It seems likely that excretion of Cu from the liver into the bile and blood (as ceruloplasmin) is inherently lacking in the LEC rat.

引用

页码：1060 / 1063

页数：4

共 19 条

[11]

Sass-Kortsak A, 1965, Adv Clin Chem, V8, P1

[12] PHENOTYPE OF PRENEOPLASTIC AND NEOPLASTIC LIVER-LESIONS DURING SPONTANEOUS LIVER CARCINOGENESIS OF LEC RATS [J].

SAWAKI, M ;

ENOMOTO, K ;

TAKAHASHI, H ;

NAKAJIMA, Y ;

MORI, M .

CARCINOGENESIS, 1990, 11 (10) :1857-1861

[13] WILSONS DISEASE [J].

SCHEINBERG, IH ;

STERNLIEB, I .

ANNUAL REVIEW OF MEDICINE, 1965, 16 :119-+

[14]

SCHOSINSKY KH, 1974, CLIN CHEM, V20, P1556

[15] EFFECTS OF SUBCUTANEOUS AND ORAL CADMIUM ON IRON-METABOLISM - ROLE OF CERULOPLASMIN AND METALLOTHIONEIN [J].

SUGAWARA, N ;

SUGAWARA, C ;

MIYAKE, H .

ARCHIVES OF TOXICOLOGY, 1984, 56 (01) :25-28

[16] RELATIONSHIP BETWEEN CERULOPLASMIN AND CU STATUS INVOLVING METALLOTHIONEIN INDUCED BY SEVERAL HEAVY-METALS IN THE MOUSE [J].

SUGAWARA, N ;

SUGAWARA, C .

ARCHIVES OF TOXICOLOGY, 1987, 59 (06) :432-436

[17]

SUGAWARA N, 1978, Journal of Toxicological Sciences, V3, P153

[18] INDUCTION AND DEGRADATION OF COPPER-INDUCED METALLOTHIONEINS IN RAT-LIVER AS STUDIED AT ISOMETALLOTHIONEIN LEVELS [J].

SUZUKI, KT ;

YAMAMURA, M .

TOXICOLOGY LETTERS, 1980, 6 (4-5) :301-307

[19] NEW MUTATION CAUSING HEREDITARY HEPATITIS IN THE LABORATORY RAT [J].

YOSHIDA, MC ;

MASUDA, R ;

SASAKI, M ;

TAKEICHI, N ;

KOBAYASHI, H ;

DEMPO, K ;

MORI, M .

JOURNAL OF HEREDITY, 1987, 78 (06) :361-365

← 1 2 →