ORAL-CANCER PROGRESSION AND C-ERBB-2 NEU PROTOONCOGENE EXPRESSION

被引：66

作者：

HOU, L

SHI, D

TU, SM

ZHANG, HZ

HUNG, MC

LING, DH

机构：

[1] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT TUMOR BIOL,BOX 79,1515 HOLCOMBE BLVD,HOUSTON,TX 77030

[2] SHANGDONG MED UNIV,DEPT ORAL PATHOL,JINAN 250012,PEOPLES R CHINA

[3] SHANGHAI MED UNIV,CANC HOSP,SHANGHAI 200032,PEOPLES R CHINA

来源：

CANCER LETTERS | 1992年 / 65卷 / 03期

关键词：

ONCOGENES; C-ERBB-2 NEU (HER-2); ORAL CARCINOMA; IMMUNOHISTOCHEMISTRY;

D O I：

10.1016/0304-3835(92)90234-M

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Monoclonal antibody PAb3 to c-erbB-2/neu protein was utilized in the immunoperoxidase staining of 86 human specimens from oral mucosa. These tissue specimens represented a spectrum from 7 normal to 9 simple hyperplasia, 15 mild dysplasia, 14 moderate dysplasia, 20 severe dysplasia and 21 squamous cell carcinoma. Our study indicated that as the cells acquire a more malignant phenotype, there was a progressive increase in neu expression. It also suggested that neu may be involved in the development of oral cancers and that its evaluation in the early stages may assist in the diagnosis and management of oral cancers.

引用

页码：215 / 220

页数：6