SYNTHESIS OF (-)-NEPLANOCIN A FROM (R,R)-TARTARIC ACID

被引：44

作者：

BESTMANN, HJ

ROTH, D

机构：

[1] Institut Für Organische Chemie, Universität Erlangen-Nürnberg, Erlangen, D-8520

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1990年 / 29卷 / 01期

关键词：

D O I：

10.1002/anie.199000991

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of the carbocyclic nuclcoside analogue 1 from (R,R)‐tartaric acid involves eleven steps via intermediary formation of the cyclopentenone 2. Since organolithium compounds other than LiGH2OCH2OCH3 can also be added to 2, any desirable 3‐substituted derivatives of 1 are, in principle, accessible in this way. (−)‐Neplanocin A is of special importance since it exhibits both antiviral as well as antitumor activity. (Figure Presented.) Copyright © 1990 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：99 / 100

页数：2

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[11] EFFICIENT PREPARATION OF [(METHOXYMETHOXY)METHYL]TRIBUTYLSTANNANE, A CONVENIENT HYDROXYMETHYL ANION EQUIVALENT [J].