APOLIPOPROTEIN-E GENOTYPE IN SPANISH PATIENTS OF ALZHEIMERS OR PARKINSONS-DISEASE

被引：32

作者：

IBARRETA, D

GOMEZISLA, T

PORTERASANCHEZ, A

PARRILLA, R

AYUSO, MS

机构：

[1] CTR INVEST BIOL,CSIC,DEPT HUMAN PHYSIOL & MOLEC GENET,E-28006 MADRID,SPAIN

[2] HOSP UNIV OCTUBRE 12,DEPT NEUROL,MADRID,SPAIN

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1995年 / 134卷 / 1-2期

关键词：

ALZHEIMERS DISEASE; PARKINSONS DISEASE; APOLIPOPROTEIN E;

D O I：

10.1016/0022-510X(95)00238-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Blood donors of the Madrid area show a 6% frequency of apolipoprotein E genotype carrying allele epsilon 4. This frequency is smaller than other populations of Caucasian origin. This proportion decreases to 4% in a selected sample of healthy individuals of ages > 60 years. The frequency (34%) of the allele epsilon 4 was significantly increased in patients of late onset Alzheimer's disease, similarly to other populations. An earlier age of onset of the dementia is observed in the patients of late-onset Alzheimer's disease carrying the allele epsilon 4. No increased frequency in allele epsilon 4 frequency was found in patients of early-onset Alzheimer's disease. Patients of Parkinson's disease do not show any differences in the frequency of the alleles of apolipoprotein E when compared with healthy individuals.

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收藏

页码：146 / 149

页数：4

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