NEUROPHYSIOLOGICAL PROPERTIES OF PALLIDAL NEURONS IN PARKINSONS-DISEASE

被引:162
作者
STERIO, D
BERIC, A
DOGALI, M
FAZZINI, E
ALFARO, G
DEVINSKY, O
机构
[1] NYU, HOSP JOINT DIS, SCH MED, DEPT NEUROL, NEW YORK, NY 10003 USA
[2] NYU, MED CTR, DEPT NEUROSURG, DIV FUNCT & STEREOTACT NEUROSURG, NEW YORK, NY 10016 USA
关键词
D O I
10.1002/ana.410350512
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Neuronal properties of the human g lobus pallidus (GP) are not known. Since GP is the major output of the basal ganglia, it may be involved in the pathophysiology of Parkinson's disease. We studied 12 patients with medically resistant Parkinson's disease by using single cell recording of the GP during stereotaxic pallidotomy to define neuronal firing rate and its modulation during active and passive movements. Different frequency and pattern of single cell activity was found in globus pallidus externus compared with globus pallidus internus. Discharge rates of 19% of GP cells were modulated by passive contralateral movements. Pallidal units were most often related solely to single joint movement. Different patterns of activity in relation to the two different movements of the same joint were often observed. We identified somatotopically arranged cell clusters that alter discharge rate with related movements. These findings suggest at least a partial somatotopic organization of the human GP and similarity with experimental results in both healthy and MPTP monkeys, providing a rationale for surgical or pharmacological targeting of GP for treating Parkinson's disease.
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页码:586 / 591
页数:6
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