INSPIRATORY PARTICLE DEPOSITION IN AIRWAY BIFURCATION MODELS

被引:31
作者
BALASHAZY, I
HOFMANN, W
MARTONEN, TB
机构
[1] DUKE UNIV,MED CTR,CTR EXTRAPOLAT MODELING,DURHAM,NC 27710
[2] HUNGARIAN ACAD SCI,CENT RES INST PHYS,H-1525 BUDAPEST,HUNGARY
[3] SALZBURG UNIV,BIOPHYS ABT,A-5020 SALZBURG,AUSTRIA
关键词
D O I
10.1016/0021-8502(91)90090-5
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
Particle deposition in a three-dimensional bifurcation model of the human lung was computed for simultaneous effects of inertial impaction and gravitational settling. In the present approach an anatomical bifurcation unit is characterized as a contiguous system of three straight tubes with two intermediate bends, with defined radius of curvature and an effective branching angle. Idealized flow profiles of uniform velocity in the straight segments and of rotational velocity in the bend portions were assumed, the latter being corrected for physiologically realistic flow conditions. Our theoretical results show excellent agreement with published experimental data. This model is then used to predict aerosol deposition in the symmetrical Model A of Weibel [Weibel, E. R. (1963) Morphometry of the Human Lung. Springer, Berlin] and to study the effect of airway variability and asymmetry on particle deposition in the human lung.
引用
收藏
页码:15 / 30
页数:16
相关论文
共 39 条
[21]  
Kim CS, 1989, J AEROSOL MED, V2, P15
[22]  
Kim CS, 1989, J AEROSOL MED, V2, P1, DOI DOI 10.1089/jam.1989.2.1
[23]  
KIM CS, 1988, J AEROSOL MED, V1, P203
[24]   ANALYSIS OF HUMAN-LUNG MORPHOMETRIC DATA FOR STOCHASTIC AEROSOL DEPOSITION CALCULATIONS [J].
KOBLINGER, L ;
HOFMANN, W .
PHYSICS IN MEDICINE AND BIOLOGY, 1985, 30 (06) :541-556
[25]  
KOBLINGER L, 1988, INHALED PARTICLES, V6, P65
[26]  
LANDAHL H. D., 1950, BULL MATH BIOPHYS, V12, P43, DOI 10.1007/BF02477345
[27]   SAMPLING OF LIQUID AEROSOLS BY WIRES, CYLINDERS, AND SLIDES, AND THE EFFICIENCY OF IMPACTION OF THE DROPLETS [J].
LANDAHL, HD ;
HERRMANN, RG .
JOURNAL OF COLLOID SCIENCE, 1949, 4 (02) :103-136
[28]   PARTICLE REMOVAL BY RESPIRATORY SYSTEM NOTE ON REMOVAL OF AIRBORNE PARTICULATES BY HUMAN RESPRIATORY TRACT WITH PARTICULAR REFERENCE TO ROLE OF DIFFUSION [J].
LANDAHL, HD .
BULLETIN OF MATHEMATICAL BIOPHYSICS, 1963, 25 (01) :29-&
[29]   ANALYTICAL MODEL OF HYGROSCOPIC PARTICLE BEHAVIOR IN HUMAN AIRWAYS [J].
MARTONEN, TB .
BULLETIN OF MATHEMATICAL BIOLOGY, 1982, 44 (03) :425-442
[30]  
MARTONEN TB, 1986, B MATH BIOL, V15, P225