SEMISYNTHESES, X-RAY CRYSTAL-STRUCTURES AND TUBULIN-BINDING PROPERTIES OF 7-OXODEACETAMIDOCOLCHICINE AND 7-OXODEACETAMIDOISOCOLCHICINE

被引：15

作者：

BANWELL, MG

PETERS, SC

GREENWOOD, RJ

MACKAY, MF

HAMEL, E

LIN, CM

机构：

[1] LA TROBE UNIV,DEPT CHEM,BUNDOORA,VIC 3083,AUSTRALIA

[2] NCI,DCT,DTP,MOLEC PHARMACOL LAB,BETHESDA,MD 20892

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1992年 / 45卷 / 10期

关键词：

D O I：

10.1071/CH9921577

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Commercially available (-)-colchicine (1) has been converted, via deacetylcolchiceine (4), into a mixture of 7-oxodeacetamidocolchicine (2) and 7-oxodeacetamidoisocolchicine (3). The X-ray structures and tubulin-binding properties of these title ketones are described.

引用

页码：1577 / 1588

页数：12

共 32 条

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Ibers J. A., 1974, INT TABLES XRAY CRYS, VIV, p[99, 149]

[22] 7-OXO-DEACETAMIDOCOLCHICEINE AND 7-BENZYLIMINO-DEACETAMIDOCOLCHICEINE 2 NOVEL PRODUCTS FROM BASE-CATALYZED REACTION OF (-)-N-BENZYLIDENE-DEACETYLCOLCHICEINE [J].