HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY (HPLC) - AN IMPORTANT TECHNIQUE IN THE STUDIES OF LIGNOCAINE AND ITS METABOLISM

被引：5

作者：

CHEN, Y

POTTER, JM

机构：

[1] Department of Clinical Pharmacology, Princess Alexandra Hosoital, Woolloongabba, Qld, 4102

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1994年 / 17卷 / 10期

关键词：

D O I：

10.1080/10826079408013545

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The high performance liquid chromatography (HPLC) assays which have been developed for the studies of lignocaine over the past 15 years have been reviewed. Studies of lignocaine and its metabolism have been benefited greatly by utilizing this modern technique. The sensitivity and process time of BPLC have been greatly improved by modifications including the use of solid-phase extraction for sample preparation. A further modification in the assay of hydroxylated derivatives is presented. In the study of lignocaine-monoetnylglycine-xylidide (MEGX) as a dynamic test of liver function, HPLC assay possesses some advantages over fluorescence polarisation immunoassay (FPIA).

引用

页码：2273 / 2289

页数：17

共 48 条

[1] SIMULTANEOUS DETERMINATION OF LIDOCAINE AND PROCAINAMIDE IN SERUM BY USE OF HIGH-PRESSURE LIQUID-CHROMATOGRAPHY [J].