REACTIVE ASTROCYTES IN THE KAINIC ACID-DAMAGED HIPPOCAMPUS HAVE THE PHENOTYPIC FEATURES OF TYPE-2 ASTROCYTES

被引:47
作者
REPRESA, A
NIQUET, J
CHARRIAUTMARLANGUE, C
BENARI, Y
机构
[1] INSERM U 29, Paris, 75014
来源
JOURNAL OF NEUROCYTOLOGY | 1993年 / 22卷 / 04期
关键词
D O I
10.1007/BF01187128
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Kainic acid treatment, a model of temporal lobe epilepsy, induces Ammon's horn sclerosis characterized by degeneration of CA3 pyramidal neurons and reactive gliosis. We now report that in kainic acid treated rats, reactive astrocytes in the hippocampus are A2B5 immunopositive and express GAP-43 immunoreactivity. A2B5 is a cell surface ganglioside selectively expressed in the glial O-2A lineage (oligodendrocytes and type-2 astrocytes in vitro). Since A2B5-positive cells were also GFAP immunoreactive, our observations suggest that hippocampal-reactive astrocytes in the epileptic process are type-2 astrocytes. GAP-43 is a membrane-associated phosphoprotein involved in neurite outgrowth. In vitro analysis showed that the glial 0-2A lineage may express this phosphoprotein. In this study, we found that GAP-43 was coexpressed in astrocytes with A2B5 suggesting that in vivo as in vitro type-2 astrocytes express GAP-43.
引用
收藏
页码:299 / 310
页数:12
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