LONG-TERM POTENTIATION IN THE AVIAN HIPPOCAMPUS DOES NOT REQUIRE ACTIVATION OF THE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR

被引：33

作者：

WIERASZKO, A ^{[1
]}

BALL, GF ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,DEPT PSYCHOL,BALTIMORE,MD 21218

来源：

SYNAPSE | 1993年 / 13卷 / 02期

关键词：

PIGEON; KYNURENIC ACID; EVOKED POTENTIAL; APV; MK-801;

D O I：

10.1002/syn.890130208

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Evoked potentials recorded from slices of pigeon hippocampus were reversibly attenuated by 2 mM kynurenic acid. High frequency stimulation (3 X 200 Hz for 1 sec, with 1 sec intervals) evoked a persistent increase in the evoked potential, lasting in a nondecremental form for at least 2 hr. This increase in the magnitude of the potential was not blocked by antagonists of the NMDA receptor (APV and MK-801). These data suggest that the synaptic facilitation observed in the pigeon hippocampus, which appears to be a form of long-term potentiation, does not depend on the activation of NMDA receptors.

引用

收藏

页码：173 / 178

页数：6

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