Cytotoxic compounds from a two-sponge association

被引:128
作者
Jung, JH
Sim, CJ
Lee, CO
机构
[1] HAN NAM UNIV,DEPT BIOL,TAEJON,SOUTH KOREA
[2] KOREA RES INST CHEM TECHNOL,PHARMACEUT SCREENING CTR,TAEJON 305606,SOUTH KOREA
来源
JOURNAL OF NATURAL PRODUCTS | 1995年 / 58卷 / 11期
关键词
D O I
10.1021/np50125a012
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Investigation of the cytotoxic constituents of a two-sponge association (Poecillastra sp. and Jaspis sp.) led to the isolation of pectenotoxin II [1] and psammaplin A as the active compounds. In an in vitro cell culture assay, 1 displayed very potent cytotoxic activities against human lung (A-549), colon (HT-29), and breast (MCF-7) cancer cell lines. Pectenotoxin II also exhibited selective cytotoxicity against several cell lines representing ovarian, renal, lung, colon, CNS, melanoma, and breast cancer, with differences in LC(50) values between sensitive and resistant cell lines of 100-fold or more.
引用
收藏
页码:1722 / 1726
页数:5
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