GENERAL-SYNTHESIS OF ENANTIOMERICALLY PURE BETA-AMINO ACIDS

被引：50

作者：

GMEINER, P

机构：

[1] Institut für Pharmazie und Lebensmittelchemie der Ludwig-Maximilians-Universität, Sophienstraße 10

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 40期

关键词：

D O I：

10.1016/S0040-4039(00)97940-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of chiral β-amino acids starling from (S)-asparagine is shown. The key intermediate is an activated β-homoserine equivalent, which can be reacted with organocuprates to yield β-N,N-dibenzylamino nitrile derivatives. After deprotection the β-amino acids are obtained enantiomerically pure in high overall yield. © 1990.

引用

页码：5717 / 5720

页数：4

共 26 条

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