INVESTIGATION OF ENTEROHEMORRHAGIC ESCHERICHIA-COLI O157-H7 ADHERENCE CHARACTERISTICS AND INVASION POTENTIAL REVEALS A NEW ATTACHMENT PATTERN SHARED BY INTESTINAL ESCHERICHIA-COLI

被引：64

作者：

MCKEE, ML ^{[1
]}

OBRIEN, AD ^{[1
]}

机构：

[1] UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT IMMUNOL & MICROBIOL,BETHESDA,MD 20814

来源：

INFECTION AND IMMUNITY | 1995年 / 63卷 / 05期

关键词：

D O I：

10.1128/IAI.63.5.2070-2074.1995

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, the interactions of enterohemorrhagic Escherichia coli (EHEC) O157 strains with human ileocecal (HCT-8) epithelial cells and HEp-2 cells were examined. EHEC adhered to, but did not invade, HCT-8 cells by the localized adherence mechanism and a heretofore unrecognized pattern which we called log jam. The log jam formation was (i) not observed on HEp-2 cells, (ii) independent of the EHEC eaeA gene required for localized adherence, and (iii) shared by pathogenic and nonpathogenic E. coli strains but not K-12 strains. The log jam phenotype may represent a basal means by which E. coli bacteria attach to the human intestine.

引用

页码：2070 / 2074

页数：5

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