ROLE OF HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX DQ MOLECULES IN SUPERANTIGENICITY OF STREPTOCOCCUS-DERIVED PROTEIN

被引:10
作者
ESAKI, Y
FUKUI, Y
SUDO, T
YAMAMOTO, K
INAMITSU, T
NISHIMURA, Y
HIROKAWA, K
KIMURA, A
SASAZUKI, T
机构
[1] KYUSHU UNIV,MED INST BIOREGULAT,DEPT GENET,HIGASHI KU,FUKUOKA 812,JAPAN
[2] KUMAMOTO UNIV,GRAD SCH MED SCI,DEPT NEUROSCI & IMMUNOL,DIV IMMUNOGENET,KUMAMOTO 860,JAPAN
[3] TOKYO METROPOLITAN GERIATR HOSP & INST GERENTOL,DEPT PATHOL,TOKYO 173,JAPAN
关键词
D O I
10.1128/IAI.62.4.1228-1235.1994
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Antigenicity of peptic extract from type 12 group A streptococci (PEAST12) for T cells was examined in major histocompatibility complex (MHC) class II transgenic mice. PEAST12 was mitogenic for murine T cells when antigen-presenting cells were obtained from human MHC (HLA)-DQ4 alpha beta transgenic mice or from DQ6 alpha beta transgenic mice but was not mitogenic in DR alpha transgenic, DR51 alpha beta transgenic, Ecu transgenic, or nontransgenic mice. In addition, PEAST12 showed mitogenicity for murine T cells in DQ4 alpha singly transgenic mice but not in DQ4 beta singly transgenic mice. T-cell stimulation by PEAST12 was unrestricted by but dependent on the expression of HLA-DQ molecules on antigen-presenting cells, and PEAST12 selectively activated T-cell receptor V beta 11-, V beta 15-, and V beta 18-positive T cells in mice. We propose that PEAST12 contains a superantigen which binds preferentially to the alpha-chain of HLA-DQ molecules. The well-known phenomenon that peptic extracts from group A streptococci are mitogenic in humans but not in mice is likely due to structural differences in MHC class II molecules between these two species of mammals.
引用
收藏
页码:1228 / 1235
页数:8
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