UNBALANCED 17 TRANSLOCATION IN MYELODYSPLASTIC SYNDROME FOLLOWING TREATMENT OF ACUTE MYELOBLASTIC-LEUKEMIA WITH AN 8,22 TRANSLOCATION

被引：9

作者：

HAMAMOTO, K ^{[1
]}

HASHIMOTONINOMIYA, A ^{[1
]}

KISHIMOTO, Y ^{[1
]}

KIMURA, T ^{[1
]}

FUJITAKE, H ^{[1
]}

YASUNAGA, K ^{[1
]}

HORIIKE, S ^{[1
]}

机构：

[1] KYOTO PREFECTURAL UNIV MED,KYOTO,JAPAN

来源：

CANCER GENETICS AND CYTOGENETICS | 1994年 / 74卷 / 01期

关键词：

D O I：

10.1016/0165-4608(94)90026-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The chromosome der(1;7)(q10;p10) consists of the short arm of chromosome 7 and the long arm of chromosome 1, and is a common abnormality in treatment-related leukemia and myelodysplastic syndrome. Here we describe a 39-year-old Japanese man with acute myeloblastic leukemia (FAB-M2) exhibiting t(8;21)(q22;q22). He entered complete remission after induction therapy, and intensification therapy including alkylating agents was subsequently continued for 3 years. The patient then developed pancytopenia; bone marrow aspiration revealed myelodysplastic syndrome exhibiting the der (1;7) chromosome. To our knowledge, this is the first reported case of such on abnormality in myelodysplastic syndrome secondary to acute myeloblastic leukemia with the 8;21 translocation.

引用

页码：35 / 39

页数：5

共 26 条

[1] DETERMINATION OF THE BREAKPOINTS OF 1-7 TRANSLOCATIONS IN MYELODYSPLASTIC SYNDROME BY INSITU HYBRIDIZATION USING CHROMOSOME-SPECIFIC ALPHA-SATELLITE DNA FROM HUMAN CHROMOSOME-1 AND CHROMOSOME-7 [J].