INCREASED RENAL-ALLOGRAFT THROMBOSIS IN CAPD PATIENTS

被引:54
作者
MURPHY, BG
HILL, CM
MIDDLETON, D
DOHERTY, CC
BROWN, JH
NELSON, WE
KERNOHAN, RM
KEANE, PK
DOUGLAS, JF
MCNAMEE, PT
机构
[1] BELFAST CITY HOSP,TISSUE TYPING LABS,BELFAST BT9 7AB,NORTH IRELAND
[2] QUEENS UNIV BELFAST,DEPT PATHOL,BELFAST BT7 1NN,ANTRIM,NORTH IRELAND
关键词
CONTINUOUS AMBULATORY PERITONEAL DIALYSIS (CAPD); TRANSPLANTATION-KIDNEY; THROMBOSIS; HEMODIALYSIS; FIBRINOGEN;
D O I
10.1093/ndt/9.8.1166
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
In a retrospective analysis of 202 renal transplant procedures in the years 1989-1992 we identified an excess of grafts lost from primary renovascular thrombosis in patients receiving continuous ambulatory peritoneal dialysis (CAPD) compared to haemodialysis (HD) patients (9 CAPD versus 0 HD, Chi-squared = 9.63; P<0.01). All graft losses from thrombosis occurred within 16 days of surgery. Possible predisposing causes were identified in three patients. Donor age was greater in CAPD patients losing their kidneys from thrombosis compared to the overall CAPD group [mean (SD) years, 43.0(12.9) versus 29.1(15.8); P = 0.01] whereas no significant difference in haematocrit, platelet count, antibody status, cyclosporin use, perioperative hypotension, primary diagnosis, smoking, or diabetes mellitus was found. Data from the EDTA registry for 1990-91 show that graft loss from primary renovascular thrombosis in UK-treated patients was reported in 7.1% of CAPD recipients compared with 1.8% in haemodialysis. We suggest that CAPD patients are at greater risk of graft loss from renovascular thrombosis than HD patients and may require more intensive fluid and anticoagulant treatment in the perioperative period.
引用
收藏
页码:1166 / 1169
页数:4
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