CYTOTOXIC T-LYMPHOCYTE LYSIS INHIBITED BY VIABLE HIV MUTANTS

被引：95

作者：

MEIER, UC

KLENERMAN, P

GRIFFIN, P

JAMES, W

KOPPE, B

LARDER, B

MCMICHAEL, A

PHILLIPS, R

机构：

[1] JOHN RADCLIFFE HOSP, NUFFIELD DEPT CLIN MED, OXFORD OX3 9DU, ENGLAND

[2] JOHN RADCLIFFE HOSP, INST MOLEC MED, OXFORD OX3 9DU, ENGLAND

[3] UNIV OXFORD, SIR WILLIAM DUNN SCH PATHOL, OXFORD OX1 3RE, ENGLAND

[4] WELLCOME RES LABS, BECKENHAM BR3 3BS, KENT, ENGLAND

来源：

SCIENCE | 1995年 / 270卷 / 5240期

关键词：

D O I：

10.1126/science.270.5240.1360

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Immune evasion by the human immunodeficiency virus (HIV) is unexplained but may involve the mutation of viral antigens. When cytotoxic T lymphocytes engaged CD4-positive cells that were acutely infected with HIV bearing natural variant epitopes in reverse transcriptase, substantial inhibition of specific antiviral lysis was observed. Mutant viruses capable of these transactive effects could facilitate the persistence of a broad range of HIV variants in the face of an active and specific immune response.

引用

收藏

页码：1360 / 1362

页数：3

相关论文

共 33 条

[1] NATURAL VARIANTS OF CYTOTOXIC EPITOPES ARE T-CELL RECEPTOR ANTAGONISTS FOR ANTIVIRAL CYTOTOXIC T-CELLS [J].

BERTOLETTI, A ;

SETTE, A ;

CHISARI, FV ;

PENNA, A ;

LEVRERO, M ;

DECARLI, M ;

FIACCADORI, F ;

FERRARI, C .

NATURE, 1994, 369 (6479) :407-410

[2] MAJOR HISTOCOMPATIBILITY COMPLEX DETERMINES SUSCEPTIBILITY TO CYTOTOXIC T-CELLS DIRECTED AGAINST MINOR HISTOCOMPATIBILITY ANTIGENS [J].

BEVAN, MJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1975, 142 (06) :1349-1364

[3] SCINTILLATION PROXIMITY ASSAY [J].

BOSWORTH, N ;

TOWERS, P .

NATURE, 1989, 341 (6238) :167-168

[4] HIV PATHOGENESIS - LINES DRAWN IN EPITOPE WARS [J].

COFFIN, JM .

NATURE, 1995, 375 (6532) :534-535

[5] DEFINITION OF THE RANGE AND DISTRIBUTION OF HUMAN-IMMUNODEFICIENCY-VIRUS MACROPHAGE TROPISM USING PCR-BASED INFECTIVITY MEASUREMENTS [J].

COLLIN, M ;

ILLEI, P ;

JAMES, W ;

GORDON, S .

JOURNAL OF GENERAL VIROLOGY, 1994, 75 :1597-1603

[6] IMPAIRED CYTOTOXIC T-LYMPHOCYTE RECOGNITION DUE TO GENETIC VARIATIONS IN THE MAIN IMMUNOGENIC REGION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS-1 NEF PROTEIN [J].

COUILLIN, I ;

CULMANNPENCIOLELLI, B ;

GOMARD, E ;

CHOPPIN, J ;

LEVY, JP ;

GUILLET, JG ;

SARAGOSTI, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (03) :1129-1134

[7]

DEBOER HA, 1983, P NATL ACAD SCI-BIOL, V80, P21

[8] EFFICIENT PROCESSING OF AN ANTIGENIC SEQUENCE FOR PRESENTATION BY MHC CLASS-I MOLECULES DEPENDS ON ITS NEIGHBORING RESIDUES IN THE PROTEIN [J].

DELVAL, M ;

SCHLICHT, HJ ;

RUPPERT, T ;

REDDEHASE, MJ ;

KOSZINOWSKI, UH .

CELL, 1991, 66 (06) :1145-1153

[9] A NEW METHOD FOR MEASURING REVERSE-TRANSCRIPTASE ACTIVITY BY ELISA [J].

EBERLE, J ;

SEIBL, R .

JOURNAL OF VIROLOGICAL METHODS, 1992, 40 (03) :347-356

[10] TICKLING THE TCR - SELECTIVE T-CELL FUNCTIONS STIMULATED BY ALTERED PEPTIDE LIGANDS [J].

EVAVOLD, BD ;

SLOANLANCASTER, J ;

ALLEN, PM .

IMMUNOLOGY TODAY, 1993, 14 (12) :602-609

← 1 2 3 4 →