THE SENSITIVITY OF LEISHMANIA SPECIES TO AMINOSIDINE

被引：76

作者：

NEAL, RA

ALLEN, S

MCCOY, N

OLLIARO, P

CROFT, SL

机构：

[1] UNIV LONDON LONDON SCH HYG & TROP MED,DEPT MED PARASITOL,LONDON WC1E 7HT,ENGLAND

[2] FARMITALIA CARLO ERBA SPA,RES & DEV,ANTI INFECT,I-20159 MILAN,ITALY

[3] UNIV PAVIA,IRCCS S MATTEO,INST INFECT DIS,I-27100 PAVIA,ITALY

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1995年 / 35卷 / 05期

关键词：

D O I：

10.1093/jac/35.5.577

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The aminoglycoside, aminosidine exhibited ED(50)s of between 1 and 5 mu M against the amastigotes of Leishmania major and Leishmania tropica in mouse peritoneal macrophages whereas other strains causing New World cutaneous leishmaniasis such as Leishmania braziliensis were more refractory. Aminosidine was also active against all but one of the Leishmania donovani strains tested and when combined with sodium stibogluconate, the drug showed marked potentiation against the amastigotes of L. donovani in vitro and an additive effect in experimentally infected BALB/c mice.

引用

页码：577 / 584

页数：8

共 24 条

[1]

Allen S., 1989, Leishmaniasis: The current status and new strategies for control. Proceedings of a NATO Advanced Study Institute on leishmaniasis: The first centenary (1885-1985), new strategies for control, Zakinthos, Greece, 20-27 September 1987., P711

[2] CORRELATION OF SINEFUNGIN SUSCEPTIBILITY AND DRUG-AFFINITY FOR PROTEIN CARBOXYMETHYLTRANSFERASE ACTIVITY IN AMERICAN LEISHMANIA SPECIES [J].