HOLLOW FIBER SUPPORTED GAS MEMBRANE FOR INSITU REMOVAL OF AMMONIUM DURING AN ANTIBIOTIC FERMENTATION

被引：18

作者：

HECHT, V ^{[1
]}

BISCHOFF, L ^{[1
]}

GERTH, K ^{[1
]}

机构：

[1] GESELL BIOTECHNOL FORSCH GMBH,DEPT MICROBIOL,W-3300 BRAUNSCHWEIG,GERMANY

来源：

BIOTECHNOLOGY AND BIOENGINEERING | 1990年 / 35卷 / 10期

关键词：

D O I：

10.1002/bit.260351012

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

To study the influence of ammonium on an antibiotic cultivation, mass transfer measurements of ammonium through microporous hydrophobic membranes using different stripping methods were carried out and compared. The higher overall mass transfer coefficients for ammonium were obtained with an acid stripping solution compared to water, vacuum, or sweeping air. A hollow fiber module for in situ removal of ammonium during cultivation was designed and operated in an external bypass to a 10‐L fermentor. Compared to a control fermentation, the cell dry mass could be increased 2.6 times and the antibiotic concentration 8 times, if the in situ ammonium removal was in operation. Copyright © 1990 John Wiley & Sons, Inc.

引用

页码：1042 / 1050

页数：9

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