EFFECT OF ALPHA(1)-ANTICHYMOTRYPSIN ON THE TOXICITY OF BETA-AMYLOID FRAGMENT-25-40 IN RAT PRIMARY CULTURED NEURONS

被引：6

作者：

KOBAYASHI, T ^{[1
]}

ABE, K ^{[1
]}

SAITO, H ^{[1
]}

NISHIYAMA, N ^{[1
]}

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL,BUNKYO KU,TOKYO 113,JAPAN

来源：

NEUROSCIENCE LETTERS | 1994年 / 172卷 / 1-2期

关键词：

ALPHA(1)-ANTICHYMOTRYPSIN; ALZHEIMERS DISEASE; BETA-AMYLOID; CELL CULTURE; NEUROTOXICITY; SURVIVAL;

D O I：

10.1016/0304-3940(94)90683-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

alpha(1)-Antichymotrypsin (ACT) and beta-amyloid have been reported to be present in senile plaques. We investigated the combination effects of ACT and a novel synthetic beta-amyloid peptide, on rat primary cultured brain neurons. ACT had no effect in high density culture and decreased the number of surviving neurons in low density cell culture. Combination of ACT with beta(25-40) did not affect the toxicity of beta(25-40) in high and low density culture.

引用

页码：147 / 150

页数：4

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