SEX-HORMONES AND HEMOSTATIC RISK-FACTORS FOR CORONARY HEART-DISEASE IN MEN WITH HYPERTENSION

被引：93

作者：

PHILLIPS, GB

JING, TY

RESNICK, LM

BARBAGALLO, M

LARAGH, JH

SEALEY, JE

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,ST LUKES ROOSEVELT HOSP CTR,DEPT MED,NEW YORK,NY 10032

[2] CORNELL UNIV,MED CTR,NEW YORK HOSP,COLL MED,CTR CARDIOVASC,NEW YORK,NY 10021

来源：

JOURNAL OF HYPERTENSION | 1993年 / 11卷 / 07期

关键词：

SEX HORMONES; HEMOSTATIC FACTORS; HYPERTENSION; TESTOSTERONE;

D O I：

10.1097/00004872-199307000-00003

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Objective and design: It has been hypothesized that risk factors for coronary heart disease in men are linked and that the underlying factor linking them may be an alteration in the sex hormone milieu. As a test of this hypothesis, sex hormones and fibrinogen, factor VII and plasminogen activator inhibitor (PAI-1), hemostatic factors recently shown to be risk factors for myocardial infarction, were measured in men with hypertension and in healthy control subjects. Results: The fasting serum testosterone and free testosterone levels were decreased and the plasma factor VII and PAI-1 levels increased in the men with hypertension. Conclusion: These findings are consistent with the stated hypothesis.

引用

页码：699 / 702

页数：4

共 41 条

[31] MULTIVARIATE-ANALYSIS OF RELATIONSHIP OF 7 VARIABLES TO BLOOD-PRESSURE - FINDINGS OF CHICAGO-HEART-ASSOCIATION DETECTION PROJECT IN INDUSTRY, 1967-1972 [J].

STAMLER, J ;

RHOMBERG, P ;

SCHOENBERGER, JA ;

SHEKELLE, RB ;

DYER, A ;

SHEKELLE, S ;

STAMLER, R ;

WANNAMAKER, J .

JOURNAL OF CHRONIC DISEASES, 1975, 28 (10) :527-548

[32]

STANIK S, 1981, J CLIN ENDOCR METAB, V53, P828, DOI 10.1210/jcem-53-4-828

[33]

STANIK S, 1973, J CLIN ENDOCR METAB, V225, P1643

[34] DIGOXIN AND ABNORMAL SERUM HORMONE LEVELS [J].

STOFFER, SS ;

HYNES, KM ;

JIANG, NS ;

RYAN, RJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1973, 225 (13) :1643-1644

[35]

STONE MC, 1985, J ROY COLL GEN PRACT, V35, P565

[36] PITUITARY-GONADAL DYSFUNCTION IN LOW-OUTPUT CARDIAC-FAILURE [J].

TAPPLER, B ;

KATZ, M .

CLINICAL ENDOCRINOLOGY, 1979, 10 (03) :219-226

[37]

WELBORN TA, 1966, LANCET, V1, P1336

[38] RELATION OF HEMOSTATIC RISK-FACTORS TO OTHER RISK-FACTORS FOR CORONARY HEART-DISEASE AND TO SEX-HORMONES IN MEN [J].

YANG, XC ;

JING, TY ;

RESNICK, LM ;

PHILLIPS, GB .

ARTERIOSCLEROSIS AND THROMBOSIS, 1993, 13 (04) :467-471

[39] FIBRINOGEN, VISCOSITY, AND WHITE BLOOD-CELL COUNT ARE MAJOR RISK-FACTORS FOR ISCHEMIC-HEART-DISEASE - THE CAERPHILLY AND SPEEDWELL COLLABORATIVE HEART-DISEASE STUDIES [J].

YARNELL, JWG ;

BAKER, IA ;

SWEETNAM, PM ;

BAINTON, D ;

OBRIEN, JR ;

WHITEHEAD, PJ ;

ELWOOD, PC .

CIRCULATION, 1991, 83 (03) :836-844

[40]

ZANNAD F, 1988, J HYPERTENS, V6, P293

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