STEREOCHEMICAL STUDIES ON MEDICINAL AGENTS .31. SYNTHESIS AND OPIOID ANTAGONIST POTENCIES OF NALTREXAMINE BIVALENT LIGANDS WITH CONFORMATIONALLY RESTRICTED SPACERS

被引：37

作者：

PORTOGHESE, PS ^{[1
]}

RONSISVALLE, G ^{[1
]}

LARSON, DL ^{[1
]}

TAKEMORI, AE ^{[1
]}

机构：

[1] UNIV MINNESOTA,SCH MED,SCH MED,DEPT PHARMACOL,MINNEAPOLIS,MN 55455

来源：

关键词：

D O I：

10.1021/jm00159a014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1650 / 1653

页数：4

共 18 条

[11] PORTOGHESE PS, J MED CHEM
[12] PORTOGHESE PS, 1985, LIFE SCI, V36, P802
[13] STIMULANT ACTIONS OF VOLATILE ANAESTHETICS ON SMOOTH MUSCLE
RANG, HP
[J]. BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1964, 22 (02): : 356 - &
[14] REIN M, 1984, THESIS U MINNESOTA
[15] STEREOSPECIFIC SYNTHESIS OF THE 6-ALPHA-AMINO AND 6-BETA-AMINO DERIVATIVES OF NALTREXONE AND OXYMORPHONE
SAYRE, LM
PORTOGHESE, PS
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1980, 45 (16) : 3366 - 3368
[16] DIMERIC TETRAPEPTIDE ENKEPHALINS DISPLAY EXTRAORDINARY SELECTIVITY FOR THE DELTA-OPIATE RECEPTOR
SHIMOHIGASHI, Y
COSTA, T
CHEN, HC
RODBARD, D
[J]. NATURE, 1982, 297 (5864) : 333 - 335
[17] SHIMOHIGASHI Y, 1982, MOL PHARMACOL, V21, P558
[18] SUGG EE, J MED CHEM