BRAZILIN STIMULATES THE GLUCOSE-TRANSPORT IN 3T3-L1 CELLS

被引：25

作者：

KIM, YM ^{[1
]}

KIM, SG ^{[1
]}

KHIL, LY ^{[1
]}

MOON, CK ^{[1
]}

机构：

[1] SEOUL NATL UNIV,COLL PHARM,GWANAK GU,SEOUL 151742,SOUTH KOREA

来源：

PLANTA MEDICA | 1995年 / 61卷 / 04期

关键词：

BRAZILIN; INSULIN SIGNAL TRANSDUCTION; 3T3-L1; CELLS; GLUCOSE TRANSPORT; PROTEIN KINASE C; INSULIN RECEPTOR AUTOPHOSPHORYLATION;

D O I：

10.1055/s-2006-958087

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Brazilin {7,11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol} was found to have hypoglycemic action and increase glucose metabolism in experimental diabetic animals. In order to investigate the mechanism of hypoglycemic action of brazilin, the effects of brazilin on glucose transport, insulin receptor autophosphorylation, and protein kinase C(PKC) activity in 3T3-L1 cells were studied. Brazilin increased basal glucose transport in 3T3-L1 fibroblasts and adipocytes. However, insulin-stimulated glucose transport was not influenced. Autophosphorylation of the partially purified insulin receptor was not affected by brazilin treatment in 3T3-L1 fibroblasts. However, brazilin decreased the PKC activity in 3T3-L1 fibroblasts and adipocytes.

引用

页码：297 / 301

页数：5

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