BRAZILIN STIMULATES THE GLUCOSE-TRANSPORT IN 3T3-L1 CELLS

被引：25

作者：

KIM, YM ^{[1
]}

KIM, SG ^{[1
]}

KHIL, LY ^{[1
]}

MOON, CK ^{[1
]}

机构：

[1] SEOUL NATL UNIV,COLL PHARM,GWANAK GU,SEOUL 151742,SOUTH KOREA

来源：

PLANTA MEDICA | 1995年 / 61卷 / 04期

关键词：

BRAZILIN; INSULIN SIGNAL TRANSDUCTION; 3T3-L1; CELLS; GLUCOSE TRANSPORT; PROTEIN KINASE C; INSULIN RECEPTOR AUTOPHOSPHORYLATION;

D O I：

10.1055/s-2006-958087

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Brazilin {7,11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol} was found to have hypoglycemic action and increase glucose metabolism in experimental diabetic animals. In order to investigate the mechanism of hypoglycemic action of brazilin, the effects of brazilin on glucose transport, insulin receptor autophosphorylation, and protein kinase C(PKC) activity in 3T3-L1 cells were studied. Brazilin increased basal glucose transport in 3T3-L1 fibroblasts and adipocytes. However, insulin-stimulated glucose transport was not influenced. Autophosphorylation of the partially purified insulin receptor was not affected by brazilin treatment in 3T3-L1 fibroblasts. However, brazilin decreased the PKC activity in 3T3-L1 fibroblasts and adipocytes.

引用

页码：297 / 301

页数：5

共 29 条

[11] INSULIN-INDUCED RECEPTOR LOSS IN CULTURED HUMAN-LYMPHOCYTES IS DUE TO ACCELERATED RECEPTOR DEGRADATION [J].

KASUGA, M ;

KAHN, CR ;

HEDO, JA ;

VANOBBERGHEN, E ;

YAMADA, KM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (11) :6917-6921

[12]

KHIL LY, 1991, THESIS SEOUL NATIONA

[13] PHORBOLESTERS ENHANCE BASAL D-GLUCOSE TRANSPORT BUT INHIBIT INSULIN STIMULATION OF D-GLUCOSE TRANSPORT AND INSULIN BINDING IN ISOLATED RAT ADIPOCYTES [J].

KIRSCH, D ;

OBERMAIER, B ;

HARING, HU .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 128 (02) :824-832

[14]

KODAWAKI T, 1984, J BIOL CHEM, V259, P14208

[15] THREONINE 1336 OF THE HUMAN INSULIN-RECEPTOR IS A MAJOR TARGET FOR PHOSPHORYLATION BY PROTEIN KINASE-C [J].

LEWIS, RE ;

CAO, L ;

PERREGAUX, D ;

CZECH, MP .

BIOCHEMISTRY, 1990, 29 (07) :1807-1813

[16] TEMPERATURE-DEPENDENT ALTERATIONS IN SUGAR TRANSPORT IN CELLS INFECTED BY A TEMPERATURE-SENSITIVE MUTANT OF ROUS SARCOMA VIRUS [J].

MARTIN, GS ;

VENUTA, S ;

WEBER, M ;

RUBIN, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1971, 68 (11) :2739-&

[17]

MOON C-K, 1990, Archives of Pharmacal Research (Seoul), V13, P359, DOI 10.1007/BF02858174

[18]

MOON C-K, 1990, Archives of Pharmacal Research (Seoul), V13, P355, DOI 10.1007/BF02858173

[19] EFFECTS OF BRAZILIN ON GLUCOSE-OXIDATION, LIPOGENESIS AND THEREIN INVOLVED ENZYMES IN ADIPOSE TISSUES FROM DIABETIC KK-MICE [J].

MOON, CK ;

LEE, SH ;

LEE, MO ;

KIM, SG .

LIFE SCIENCES, 1993, 53 (16) :1291-1297

[20]

OBERMAIER B, 1987, DIABETOLOGIA, V30, P93

← 1 2 3 →