TRANSCRIPTION FACTOR TFIIB SITES IMPORTANT FOR INTERACTION WITH PROMOTER-BOUND TFIID

被引:50
作者
YAMASHITA, S
HISATAKE, K
KOKUBO, T
DOI, K
ROEDER, RG
HORIKOSHI, M
NAKATANI, Y
机构
[1] NINCDS,BETHESDA,MD 20892
[2] ROCKEFELLER UNIV,BIOCHEM & MOLEC BIOL LAB,NEW YORK,NY 10021
[3] NIDCD,NEUROCHEM LAB,BETHESDA,MD 20892
[4] UNIV TOKYO,INST APPL MICROBIOL,BUNKYO KU,TOKYO 113,JAPAN
关键词
D O I
10.1126/science.8332911
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Transcription initiation factor TFIIB recruits RNA polymerase II to the promoter subsequent to interaction with a preformed TFIID-promoter complex. The domains of TFIIB required for binding to the TFIID-promoter complex and for transcription initiation have been determined. The carboxyl-terminal two-thirds of TFIIB, which contains two direct repeats and two basic residue repeats, is sufficient for interaction with the TFIID-promoter complex. An extra 84-residue amino-terminal region, with no obvious known structural motifs, is required for basal transcription activity. Basic residues within the second basic repeat of TFIIB are necessary for stable interaction with the TFIID-promoter complex, whereas the basic character of the first basic repeat is not. Functional roles of other potential structural motifs are discussed in light of the present study.
引用
收藏
页码:463 / 466
页数:4
相关论文
共 16 条
[11]   THE YEAST SUA7 GENE ENCODES A HOMOLOG OF HUMAN TRANSCRIPTION FACTOR TFIIB AND IS REQUIRED FOR NORMAL START SITE SELECTION INVIVO [J].
PINTO, I ;
WARE, DE ;
HAMPSEY, M .
CELL, 1992, 68 (05) :977-988
[12]   THE COMPLEXITIES OF EUKARYOTIC TRANSCRIPTION INITIATION - REGULATION OF PREINITIATION COMPLEX ASSEMBLY [J].
ROEDER, RG .
TRENDS IN BIOCHEMICAL SCIENCES, 1991, 16 (11) :402-408
[13]  
STUDIER FW, 1990, METHOD ENZYMOL, V185, P60
[14]   FUNCTIONAL-ANALYSIS OF DROSOPHILA TRANSCRIPTION FACTOR-IIB [J].
WAMPLER, SL ;
KADONAGA, JT .
GENES & DEVELOPMENT, 1992, 6 (08) :1542-1552
[15]   A BIPARTITE DNA-BINDING DOMAIN COMPOSED OF DIRECT REPEATS IN THE TATA BOX BINDING FACTOR-TFIID [J].
YAMAMOTO, T ;
HORIKOSHI, M ;
WANG, J ;
HASEGAWA, S ;
WEIL, PA ;
ROEDER, RG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (07) :2844-2848
[16]   ISOLATION AND CHARACTERIZATION OF A CDNA-ENCODING DROSOPHILA TRANSCRIPTION FACTOR-TFIIB [J].
YAMASHITA, S ;
WADA, K ;
HORIKOSHI, M ;
GONG, DW ;
KOKUBO, T ;
HISATAKE, K ;
YOKOTANI, N ;
MALIK, S ;
ROEDER, RG ;
NAKATANI, Y .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (07) :2839-2843